inclusion criteria: * confirmed sars cov-2 infection (pcr-test) * oxygen therapy (maximum 'high-flow' therapy) * crp plasma concentration ≥ 50 mg/l and/or * crp increase ≥ 15 mg/l within 24 h after admission. * completed informed consent and written informed consent. * legal capacity

inclusion criteria: * confirmed sars cov-2 infection (pcr-test) * oxygen therapy (maximum 'high-flow' therapy) * crp plasma concentration ≥ 50 mg/l and/or * crp increase ≥ 15 mg/l within 24 h after admission. * completed informed consent and written informed consent. * legal capacity

inclusion criteria: confirmed sars cov-2 infection (pcr-test) oxygen therapy (maximum 'high-flow' therapy) crp plasma concentration ≥ 50 mg/l and/or crp increase ≥ 15 mg/l within 24 h after admission. completed informed consent and written informed consent. legal capacity

inclusion criteria: confirmed sars cov-2 infection (pcr-test) oxygen therapy (maximum 'high-flow' therapy) crp plasma concentration ≥ 50 mg/l and/or crp increase ≥ 15 mg/l within 24 h after admission. completed informed consent and written informed consent. legal capacity

inclusion criteria: - confirmed sars cov-2 infection (pcr-test) - oxygen therapy (maximum 'high-flow' therapy) - crp plasma concentration ≥ 25 mg/l - crp increase ≥ 15mg/l within 48h after admission. - completed informed consent and written informed consent. - legal capacity

inclusion criteria: - confirmed sars cov-2 infection (pcr-test) - oxygen therapy (maximum 'high-flow' therapy) - crp plasma concentration ≥ 25 mg/l - crp increase ≥ 15mg/l within 48h after admission. - completed informed consent and written informed consent. - legal capacity