- the patient's decision to withdraw from the study - refusing to take the probiotic for a reason not related to the development of side effects. non-inclusion criteria: - age over 75 years old or under 18 years old, - taking probiotics for 3 months prior to admission - history of intolerance to probiotics or their components - refusal to participate and sign informed consent - pregnancy or breastfeeding - presence of cancer or psychoemotional disorders - renal failure at the time of admission (glomerular filtration rate less than 50 ml / min) - hepatic failure at the time of admission (equivalent to cirrhosis class b or c on the child-pugh scale)

- the patient's decision to withdraw from the study - refusing to take the probiotic for a reason not related to the development of side effects. non-inclusion criteria: - age over 75 years old or under 18 years old, - taking probiotics for 3 months prior to admission - history of intolerance to probiotics or their components - refusal to participate and sign informed consent - pregnancy or breastfeeding - presence of cancer or psychoemotional disorders - renal failure at the time of admission (glomerular filtration rate less than 50 ml / min) - hepatic failure at the time of admission (equivalent to cirrhosis class b or c on the child-pugh scale)