inclusion criteria: - comply with the observation age of this clinical trial: 18-59 years old (both included) adults. - the subjects themselves voluntarily agreed to participate in the study, and signed an informed consent form, and can provide legal identification; understand and abide by the requirements of the trial protocol; can participate in a half-year follow-up. - body temperature under armpit <37.3 ℃. - body mass index (bmi) at 18-28kg / m² (inclusive). - female and male subjects of childbearing age took effective contraception during the study.

inclusion criteria: - comply with the observation age of this clinical trial: 18-59 years old (both included) adults. - the subjects themselves voluntarily agreed to participate in the study, and signed an informed consent form, and can provide legal identification; understand and abide by the requirements of the trial protocol; can participate in a half-year follow-up. - body temperature under armpit <37.3 ℃. - body mass index (bmi) at 18-28kg / m² (inclusive). - female and male subjects of childbearing age took effective contraception during the study.