the vital signs, physical examination and laboratory test indicators of the population specified in the plan are abnormal and have clinical significance as determined by the clinician; have a history of severe allergies to any component of the research vaccine, including aluminum preparations, such as: anaphylactic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, local allergic necrosis (arthus reaction); or any previous history of serious side effects of vaccines or drugs, such as allergies, urticaria, skin eczema, dyspnea, angioedema, etc . those with a history of sars and covid-19, meet any of the following: previous history of sars-cov and sars-cov-2 infection or morbidity; during the current sars-cov-2 epidemic, there is a diagnosis with the new crown patient / suspected patient contact history; positive for sars-cov-2 igm and / or igg antibodies; positive for real-time fluorescent rt-pcr nucleic acid. have taken antipyretics or painkillers within 24 hours before the first dose of vaccine. inoculate subunit vaccine and inactivated vaccine within 14 days before the first dose of vaccination, and inoculate live attenuated vaccine within 30 days. people with the following diseases: acute febrile illness; digestive system diseases (eg, diarrhea, abdominal pain, vomiting, etc.) in the past 7 days; congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc .; congenital or acquired immunodeficiency or autoimmune disease history or within 6 months of receiving immunomodulator treatment, such as hormones; or monoclonal antibodies; or thymosin; or interferon, etc .; but local medications (such as ointment are allowed , eye drops, inhalation or nasal spray), local administration should not exceed the dosage recommended in the instructions or have any signs of systemic exposure; the chest imaging examination is clinically significant if the investigator judges that the abnormality is clinically positive, or any positive of hepatitis b surface antigen, hepatitis c virus antibody, human immunodeficiency virus hiv antibody or syphilis specific antibody; neurological diseases or neurodevelopmental disorders (eg, migraine, epilepsy, stroke, seizures in the last three years, encephalopathy, focal neurological deficit, guillain-barré syndrome, encephalomyelitis or transverse myelitis ); history of mental illness or family history; functional spleenlessness, and spleenlessness or splenectomy for any reason; there are serious chronic diseases or conditions that cannot be controlled smoothly in the advanced stage, such as diabetes and thyroid disease; severe liver and kidney diseases; respiratory diseases that currently require daily medication (eg, chronic obstructive pulmonary disease [copd], asthma) or any treatment that exacerbates respiratory diseases (eg, exacerbated asthma) within the last 5 years; suffers history of severe cardiovascular disease (such as congestive heart failure, cardiomyopathy, ischemic heart disease, arrhythmia, conduction block, myocardial infarction, pulmonary heart disease) or myocarditis or pericarditis; have thrombocytopenia, any coagulopathy, or receive anticoagulant treatment, etc .; cancer patients; have received blood or blood-related products, including immunoglobulin within 3 months; or plan to use it during the study. lactating women or pregnant women (including blood or urine pregnancy test positive). any research or unregistered product (medicine, vaccine, biological product or device) other than the research product was used within 3 months before the application of the test drug / vaccine, or planned to be used during the study. people with halo and halo needles. the investigator believes that the presence of any disease or condition in the subject may put the subject at an unacceptable risk; the subject cannot meet the protocol requirements; and interfere with the assessment of vaccine response.

the vital signs, physical examination and laboratory test indicators of the population specified in the plan are abnormal and have clinical significance as determined by the clinician; have a history of severe allergies to any component of the research vaccine, including aluminum preparations, such as: anaphylactic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, local allergic necrosis (arthus reaction); or any previous history of serious side effects of vaccines or drugs, such as allergies, urticaria, skin eczema, dyspnea, angioedema, etc . those with a history of sars and covid-19, meet any of the following: previous history of sars-cov and sars-cov-2 infection or morbidity; during the current sars-cov-2 epidemic, there is a diagnosis with the new crown patient / suspected patient contact history; positive for sars-cov-2 igm and / or igg antibodies; positive for real-time fluorescent rt-pcr nucleic acid. have taken antipyretics or painkillers within 24 hours before the first dose of vaccine. inoculate subunit vaccine and inactivated vaccine within 14 days before the first dose of vaccination, and inoculate live attenuated vaccine within 30 days. people with the following diseases: acute febrile illness; digestive system diseases (eg, diarrhea, abdominal pain, vomiting, etc.) in the past 7 days; congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc .; congenital or acquired immunodeficiency or autoimmune disease history or within 6 months of receiving immunomodulator treatment, such as hormones; or monoclonal antibodies; or thymosin; or interferon, etc .; but local medications (such as ointment are allowed , eye drops, inhalation or nasal spray), local administration should not exceed the dosage recommended in the instructions or have any signs of systemic exposure; the chest imaging examination is clinically significant if the investigator judges that the abnormality is clinically positive, or any positive of hepatitis b surface antigen, hepatitis c virus antibody, human immunodeficiency virus hiv antibody or syphilis specific antibody; neurological diseases or neurodevelopmental disorders (eg, migraine, epilepsy, stroke, seizures in the last three years, encephalopathy, focal neurological deficit, guillain-barré syndrome, encephalomyelitis or transverse myelitis ); history of mental illness or family history; functional spleenlessness, and spleenlessness or splenectomy for any reason; there are serious chronic diseases or conditions that cannot be controlled smoothly in the advanced stage, such as diabetes and thyroid disease; severe liver and kidney diseases; respiratory diseases that currently require daily medication (eg, chronic obstructive pulmonary disease [copd], asthma) or any treatment that exacerbates respiratory diseases (eg, exacerbated asthma) within the last 5 years; suffers history of severe cardiovascular disease (such as congestive heart failure, cardiomyopathy, ischemic heart disease, arrhythmia, conduction block, myocardial infarction, pulmonary heart disease) or myocarditis or pericarditis; have thrombocytopenia, any coagulopathy, or receive anticoagulant treatment, etc .; cancer patients; have received blood or blood-related products, including immunoglobulin within 3 months; or plan to use it during the study. lactating women or pregnant women (including blood or urine pregnancy test positive). any research or unregistered product (medicine, vaccine, biological product or device) other than the research product was used within 3 months before the application of the test drug / vaccine, or planned to be used during the study. people with halo and halo needles. the investigator believes that the presence of any disease or condition in the subject may put the subject at an unacceptable risk; the subject cannot meet the protocol requirements; and interfere with the assessment of vaccine response.

- the vital signs, physical examination and laboratory test indicators of the population specified in the plan are abnormal and have clinical significance as determined by the clinician; - have a history of severe allergies to any component of the research vaccine, including aluminum preparations, such as: anaphylactic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, local allergic necrosis (arthus reaction); or any previous history of serious side effects of vaccines or drugs, such as allergies, urticaria, skin eczema, dyspnea, angioedema, etc . - those with a history of sars and covid-19, meet any of the following: 1. previous history of sars-cov and sars-cov-2 infection or morbidity; 2. during the current sars-cov-2 epidemic, there is a diagnosis with the new crown patient / suspected patient contact history; 3. positive for sars-cov-2 igm and / or igg antibodies; 4. positive for real-time fluorescent rt-pcr nucleic acid. - have taken antipyretics or painkillers within 24 hours before the first dose of vaccine. - inoculate subunit vaccine and inactivated vaccine within 14 days before the first dose of vaccination, and inoculate live attenuated vaccine within 30 days. - people with the following diseases: 1. acute febrile illness; 2. digestive system diseases (eg, diarrhea, abdominal pain, vomiting, etc.) in the past 7 days; 3. congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc .; 4. congenital or acquired immunodeficiency or autoimmune disease history or within 6 months of receiving immunomodulator treatment, such as hormones; or monoclonal antibodies; or thymosin; or interferon, etc .; but local medications (such as ointment are allowed , eye drops, inhalation or nasal spray), local administration should not exceed the dosage recommended in the instructions or have any signs of systemic exposure; 5. the chest imaging examination is clinically significant if the investigator judges that the abnormality is clinically positive, or any positive of hepatitis b surface antigen, hepatitis c virus antibody, human immunodeficiency virus hiv antibody or syphilis specific antibody; 6. neurological diseases or neurodevelopmental disorders (eg, migraine, epilepsy, stroke, seizures in the last three years, encephalopathy, focal neurological deficit, guillain-barré syndrome, encephalomyelitis or transverse myelitis ); history of mental illness or family history; 7. functional spleenlessness, and spleenlessness or splenectomy for any reason; 8. there are serious chronic diseases or conditions that cannot be controlled smoothly in the advanced stage, such as diabetes and thyroid disease; 9. severe liver and kidney diseases; respiratory diseases that currently require daily medication (eg, chronic obstructive pulmonary disease [copd], asthma) or any treatment that exacerbates respiratory diseases (eg, exacerbated asthma) within the last 5 years; suffers history of severe cardiovascular disease (such as congestive heart failure, cardiomyopathy, ischemic heart disease, arrhythmia, conduction block, myocardial infarction, pulmonary heart disease) or myocarditis or pericarditis; 10. have thrombocytopenia, any coagulopathy, or receive anticoagulant treatment, etc .; 11. cancer patients; 12. have received blood or blood-related products, including immunoglobulin within 3 months; or plan to use it during the study. - lactating women or pregnant women (including blood or urine pregnancy test positive). - any research or unregistered product (medicine, vaccine, biological product or device) other than the research product was used within 3 months before the application of the test drug / vaccine, or planned to be used during the study. - people with halo and halo needles. - the investigator believes that the presence of any disease or condition in the subject may put the subject at an unacceptable risk; the subject cannot meet the protocol requirements; and interfere with the assessment of vaccine response.

- the vital signs, physical examination and laboratory test indicators of the population specified in the plan are abnormal and have clinical significance as determined by the clinician; - have a history of severe allergies to any component of the research vaccine, including aluminum preparations, such as: anaphylactic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, local allergic necrosis (arthus reaction); or any previous history of serious side effects of vaccines or drugs, such as allergies, urticaria, skin eczema, dyspnea, angioedema, etc . - those with a history of sars and covid-19, meet any of the following: 1. previous history of sars-cov and sars-cov-2 infection or morbidity; 2. during the current sars-cov-2 epidemic, there is a diagnosis with the new crown patient / suspected patient contact history; 3. positive for sars-cov-2 igm and / or igg antibodies; 4. positive for real-time fluorescent rt-pcr nucleic acid. - have taken antipyretics or painkillers within 24 hours before the first dose of vaccine. - inoculate subunit vaccine and inactivated vaccine within 14 days before the first dose of vaccination, and inoculate live attenuated vaccine within 30 days. - people with the following diseases: 1. acute febrile illness; 2. digestive system diseases (eg, diarrhea, abdominal pain, vomiting, etc.) in the past 7 days; 3. congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc .; 4. congenital or acquired immunodeficiency or autoimmune disease history or within 6 months of receiving immunomodulator treatment, such as hormones; or monoclonal antibodies; or thymosin; or interferon, etc .; but local medications (such as ointment are allowed , eye drops, inhalation or nasal spray), local administration should not exceed the dosage recommended in the instructions or have any signs of systemic exposure; 5. the chest imaging examination is clinically significant if the investigator judges that the abnormality is clinically positive, or any positive of hepatitis b surface antigen, hepatitis c virus antibody, human immunodeficiency virus hiv antibody or syphilis specific antibody; 6. neurological diseases or neurodevelopmental disorders (eg, migraine, epilepsy, stroke, seizures in the last three years, encephalopathy, focal neurological deficit, guillain-barré syndrome, encephalomyelitis or transverse myelitis ); history of mental illness or family history; 7. functional spleenlessness, and spleenlessness or splenectomy for any reason; 8. there are serious chronic diseases or conditions that cannot be controlled smoothly in the advanced stage, such as diabetes and thyroid disease; 9. severe liver and kidney diseases; respiratory diseases that currently require daily medication (eg, chronic obstructive pulmonary disease [copd], asthma) or any treatment that exacerbates respiratory diseases (eg, exacerbated asthma) within the last 5 years; suffers history of severe cardiovascular disease (such as congestive heart failure, cardiomyopathy, ischemic heart disease, arrhythmia, conduction block, myocardial infarction, pulmonary heart disease) or myocarditis or pericarditis; 10. have thrombocytopenia, any coagulopathy, or receive anticoagulant treatment, etc .; 11. cancer patients; 12. have received blood or blood-related products, including immunoglobulin within 3 months; or plan to use it during the study. - lactating women or pregnant women (including blood or urine pregnancy test positive). - any research or unregistered product (medicine, vaccine, biological product or device) other than the research product was used within 3 months before the application of the test drug / vaccine, or planned to be used during the study. - people with halo and halo needles. - the investigator believes that the presence of any disease or condition in the subject may put the subject at an unacceptable risk; the subject cannot meet the protocol requirements; and interfere with the assessment of vaccine response.