- severe vomiting or difficulty ingesting medication - woman who are pregnant or during lactation - patients received lopinavir/ridonavir, ribavirin, interferon and monoclonal antibody specific antiviral drugs three days before enrollment - cases of respiratory failure requiring mechanical ventilation - shock - combined with other organ failure and requires icu care - clinical prognostic non-survival, palliative care, or in deep coma and no have response to supportive treatment within three hours of admission

- severe vomiting or difficulty ingesting medication - woman who are pregnant or during lactation - patients received lopinavir/ridonavir, ribavirin, interferon and monoclonal antibody specific antiviral drugs three days before enrollment - cases of respiratory failure requiring mechanical ventilation - shock - combined with other organ failure and requires icu care - clinical prognostic non-survival, palliative care, or in deep coma and no have response to supportive treatment within three hours of admission