inclusion criteria: - in sputum, throat swab, lower respiratory tract secretion, blood and other samples, the nucleic acid of the novel coronavirus was positive, or the sequencing of the virus gene was highly homologous with the known novel coronavirus - age is between 18-80 years old, the weight is more than 30kg, and there is no limit for men and women - the following conditions were met: creatinine ≤ 110 umol / l, creatinine clearance rate (egfr) ≥ 60 ml / min / 1.73m2, ast and alt ≤ 5 × uln, tbil ≤ 2 × uln; - the subjects should fully understand the purpose, nature, method and possible reaction of the study, voluntarily participate in the study and sign the informed consent.

inclusion criteria: - in sputum, throat swab, lower respiratory tract secretion, blood and other samples, the nucleic acid of the novel coronavirus was positive, or the sequencing of the virus gene was highly homologous with the known novel coronavirus - age is between 18-80 years old, the weight is more than 30kg, and there is no limit for men and women - the following conditions were met: creatinine ≤ 110 umol / l, creatinine clearance rate (egfr) ≥ 60 ml / min / 1.73m2, ast and alt ≤ 5 × uln, tbil ≤ 2 × uln; - the subjects should fully understand the purpose, nature, method and possible reaction of the study, voluntarily participate in the study and sign the informed consent.