1. pregnancy, lactation and those who are not pregnant but do not take effective contraceptive measures, in women of childbearing age. absence of pregnancy will be confirmed through urine pregnancy test. 2. patients who have participated or are participating in a clinical trial of an experimental vaccine for sars-cov-2 or coronavirus during the study or within 30 days. 3. inability to provide informed consent or to comply with study requirements. 4. patients with the following concomitant or past medical history: * both hypertension and diabetes mellitus. * both hypertension and chronic kidney disease. * both diabetes mellitus and chronic kidney disease. 5. history or evidence of alcohol abuse. 6. history or evidence of consumption of illicit drugs. 7. patients requiring mechanical ventilation. 8. patients who are determined by the principal investigator to be unsuitable for study enrollment for other reasons. 9. any medical disease or condition that, in the opinion of the site principal investigator or sub-investigator, precludes study participation. including acute, subacute, intermittent or chronic medical disease or condition that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject's successful completion of this trial.

1. pregnancy, lactation and those who are not pregnant but do not take effective contraceptive measures, in women of childbearing age. absence of pregnancy will be confirmed through urine pregnancy test. 2. patients who have participated or are participating in a clinical trial of an experimental vaccine for sars-cov-2 or coronavirus during the study or within 30 days. 3. inability to provide informed consent or to comply with study requirements. 4. patients with the following concomitant or past medical history: * both hypertension and diabetes mellitus. * both hypertension and chronic kidney disease. * both diabetes mellitus and chronic kidney disease. 5. history or evidence of alcohol abuse. 6. history or evidence of consumption of illicit drugs. 7. patients requiring mechanical ventilation. 8. patients who are determined by the principal investigator to be unsuitable for study enrollment for other reasons. 9. any medical disease or condition that, in the opinion of the site principal investigator or sub-investigator, precludes study participation. including acute, subacute, intermittent or chronic medical disease or condition that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject's successful completion of this trial.

pregnancy, lactation and those who are not pregnant but do not take effective contraceptive measures, in women of childbearing age. absence of pregnancy will be confirmed through urine pregnancy test. patients who have participated or are participating in a clinical trial of an experimental vaccine for sars-cov-2 or coronavirus during the study or within 30 days. inability to provide informed consent or to comply with study requirements. patients with the following concomitant or past medical history: both hypertension and diabetes mellitus. both hypertension and chronic kidney disease. both diabetes mellitus and chronic kidney disease. history or evidence of alcohol abuse. history or evidence of consumption of illicit drugs. patients requiring mechanical ventilation. patients who are determined by the principal investigator to be unsuitable for study enrollment for other reasons. any medical disease or condition that, in the opinion of the site principal investigator or sub-investigator, precludes study participation. including acute, subacute, intermittent or chronic medical disease or condition that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject's successful completion of this trial.

pregnancy, lactation and those who are not pregnant but do not take effective contraceptive measures, in women of childbearing age. absence of pregnancy will be confirmed through urine pregnancy test. patients who have participated or are participating in a clinical trial of an experimental vaccine for sars-cov-2 or coronavirus during the study or within 30 days. inability to provide informed consent or to comply with study requirements. patients with the following concomitant or past medical history: both hypertension and diabetes mellitus. both hypertension and chronic kidney disease. both diabetes mellitus and chronic kidney disease. history or evidence of alcohol abuse. history or evidence of consumption of illicit drugs. patients requiring mechanical ventilation. patients who are determined by the principal investigator to be unsuitable for study enrollment for other reasons. any medical disease or condition that, in the opinion of the site principal investigator or sub-investigator, precludes study participation. including acute, subacute, intermittent or chronic medical disease or condition that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject's successful completion of this trial.

- pregnancy, lactation and those who are not pregnant but do not take effective contraceptive measures. - patients who are participating in other clinical trials or have intake of investigational drug within the previous 30 days. - inability to provide informed consent or to comply with test requirements. - acute intercurrent infections such as hepatitis c virus (hcv), hepatitis b virus (hbv), human immunodeficiency virus (hiv) or syphilis. - any medical disease or condition that, in the opinion of the site principal investigator or sub-investigator, precludes study participation. including acute, subacute, intermittent or chronic medical disease or condition that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject's successful completion of this trial. - receipt of any other sars-cov-2 or other experimental coronavirus vaccine at any time prior to or during the study.

- pregnancy, lactation and those who are not pregnant but do not take effective contraceptive measures. - patients who are participating in other clinical trials or have intake of investigational drug within the previous 30 days. - inability to provide informed consent or to comply with test requirements. - acute intercurrent infections such as hepatitis c virus (hcv), hepatitis b virus (hbv), human immunodeficiency virus (hiv) or syphilis. - any medical disease or condition that, in the opinion of the site principal investigator or sub-investigator, precludes study participation. including acute, subacute, intermittent or chronic medical disease or condition that would place the subject at an unacceptable risk of injury, render the subject unable to meet the requirements of the protocol, or may interfere with the evaluation of responses or the subject's successful completion of this trial. - receipt of any other sars-cov-2 or other experimental coronavirus vaccine at any time prior to or during the study.