inclusion criteria: 1. age 18 or older 2. positive revere transcription polymerase chain reaction (rt-pcr) for covid-19 in a respiratory track sample 3. acute (less than 36 hours) onset of moderate to severe ards, as defined by berlin criteria: * having pneumonia or worsening respiratory symptoms * bilateral pulmonary infiltrates on chest imaging (x-ray of ct scan) * pulmonary wedge pressure \<18 mmhg or no clinical signs of left heart failure * hypoxemia: arterial oxygen pressure/fraction of inspired oxygen (pao2/fio2 ratio) \<200mmhg, moderate dyspnea with signs of important respiratory workload, tachypnoea \>30bpm 4. rise of inflammatory biomarkers: c-reactive protein (crp) \>10 mg/l

inclusion criteria: 1. age 18 or older 2. positive revere transcription polymerase chain reaction (rt-pcr) for covid-19 in a respiratory track sample 3. acute (less than 36 hours) onset of moderate to severe ards, as defined by berlin criteria: * having pneumonia or worsening respiratory symptoms * bilateral pulmonary infiltrates on chest imaging (x-ray of ct scan) * pulmonary wedge pressure \<18 mmhg or no clinical signs of left heart failure * hypoxemia: arterial oxygen pressure/fraction of inspired oxygen (pao2/fio2 ratio) \<200mmhg, moderate dyspnea with signs of important respiratory workload, tachypnoea \>30bpm 4. rise of inflammatory biomarkers: c-reactive protein (crp) \>10 mg/l

inclusion criteria: age 18 or older positive revere transcription polymerase chain reaction (rt-pcr) for covid-19 in a respiratory track sample acute (less than 36 hours) onset of moderate to severe ards, as defined by berlin criteria: having pneumonia or worsening respiratory symptoms bilateral pulmonary infiltrates on chest imaging (x-ray of ct scan) pulmonary wedge pressure <18 mmhg or no clinical signs of left heart failure hypoxemia: arterial oxygen pressure/fraction of inspired oxygen (pao2/fio2 ratio) <200mmhg, moderate dyspnea with signs of important respiratory workload, tachypnoea >30bpm rise of inflammatory biomarkers: c-reactive protein (crp) >10 mg/l

inclusion criteria: age 18 or older positive revere transcription polymerase chain reaction (rt-pcr) for covid-19 in a respiratory track sample acute (less than 36 hours) onset of moderate to severe ards, as defined by berlin criteria: having pneumonia or worsening respiratory symptoms bilateral pulmonary infiltrates on chest imaging (x-ray of ct scan) pulmonary wedge pressure <18 mmhg or no clinical signs of left heart failure hypoxemia: arterial oxygen pressure/fraction of inspired oxygen (pao2/fio2 ratio) <200mmhg, moderate dyspnea with signs of important respiratory workload, tachypnoea >30bpm rise of inflammatory biomarkers: c-reactive protein (crp) >10 mg/l

inclusion criteria: 1. age 18 or older 2. positive revere transcription polymerase chain reaction (rt-pcr) for covid-19 in a respiratory track sample 3. acute (less than 36 hours) onset of moderate to severe ards, as defined by berlin criteria: - having pneumonia or worsening respiratory symptoms - bilateral pulmonary infiltrates on chest imaging (x-ray of ct scan) - pulmonary wedge pressure <18 mmhg or no clinical signs of left heart failure - hypoxemia: arterial oxygen pressure/fraction of inspired oxygen (pao2/fio2 ratio) <200mmhg, moderate dyspnea with signs of important respiratory workload, tachypnoea >30bpm 4. rise of inflammatory biomarkers: c-reactive protein (crp) >10 mg/l

inclusion criteria: 1. age 18 or older 2. positive revere transcription polymerase chain reaction (rt-pcr) for covid-19 in a respiratory track sample 3. acute (less than 36 hours) onset of moderate to severe ards, as defined by berlin criteria: - having pneumonia or worsening respiratory symptoms - bilateral pulmonary infiltrates on chest imaging (x-ray of ct scan) - pulmonary wedge pressure <18 mmhg or no clinical signs of left heart failure - hypoxemia: arterial oxygen pressure/fraction of inspired oxygen (pao2/fio2 ratio) <200mmhg, moderate dyspnea with signs of important respiratory workload, tachypnoea >30bpm 4. rise of inflammatory biomarkers: c-reactive protein (crp) >10 mg/l