1. patients with a known contraindication for anticoagulation 2. pregnancy or breast feeding 3. patient already included in another research study 4. decision by a physician that involvement in the study is not in the patient's best interest 5. failure to have patient's authorization. in case of a mechanical intubated patient, lack of authorization from a first line family member 6. multi-organ failure 7. patients treated with tocilizumab at the time of start filtration

1. patients with a known contraindication for anticoagulation 2. pregnancy or breast feeding 3. patient already included in another research study 4. decision by a physician that involvement in the study is not in the patient's best interest 5. failure to have patient's authorization. in case of a mechanical intubated patient, lack of authorization from a first line family member 6. multi-organ failure 7. patients treated with tocilizumab at the time of start filtration

patients with a known contraindication for anticoagulation pregnancy or breast feeding patient already included in another research study decision by a physician that involvement in the study is not in the patient's best interest failure to have patient's authorization. in case of a mechanical intubated patient, lack of authorization from a first line family member multi-organ failure patients treated with tocilizumab at the time of start filtration

patients with a known contraindication for anticoagulation pregnancy or breast feeding patient already included in another research study decision by a physician that involvement in the study is not in the patient's best interest failure to have patient's authorization. in case of a mechanical intubated patient, lack of authorization from a first line family member multi-organ failure patients treated with tocilizumab at the time of start filtration

1. patients with a known contraindication for anticoagulation 2. pregnancy or breast feeding 3. patient already included in another research study 4. decision by a physician that involvement in the study is not in the patient's best interest 5. failure to have patient's authorization. in case of a mechanical intubated patient, lack of authorization from a first line family member 6. multi-organ failure 7. patients treated with tocilizumab at the time of start filtration

1. patients with a known contraindication for anticoagulation 2. pregnancy or breast feeding 3. patient already included in another research study 4. decision by a physician that involvement in the study is not in the patient's best interest 5. failure to have patient's authorization. in case of a mechanical intubated patient, lack of authorization from a first line family member 6. multi-organ failure 7. patients treated with tocilizumab at the time of start filtration