inclusion criteria: * males and females aged \> 18 years; * patients with flu syndrome (fever greater than 37.8c or feverish feeling referred by the patient associated with at least 1 respiratory symptom: cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose, signs cyanosis, flapping of the nose and dyspnoea); * diagnosis confirmed by real-time pcr or suspected covid-19; * hospitalized patients with: * moderate disease: hypoxemia with o2 saturation \<93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute and / or radiological evidence of pneumonia with pulmonary impairment less than 50%; or * serious illness: hospitalized patients with hypoxemia with o2 saturation \<93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute with radiological evidence of pneumonia with pulmonary involvement above 50% and / or the presence of sepsis ( organ failure) or need for invasive mechanical ventilation.

inclusion criteria: * males and females aged \> 18 years; * patients with flu syndrome (fever greater than 37.8c or feverish feeling referred by the patient associated with at least 1 respiratory symptom: cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose, signs cyanosis, flapping of the nose and dyspnoea); * diagnosis confirmed by real-time pcr or suspected covid-19; * hospitalized patients with: * moderate disease: hypoxemia with o2 saturation \<93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute and / or radiological evidence of pneumonia with pulmonary impairment less than 50%; or * serious illness: hospitalized patients with hypoxemia with o2 saturation \<93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute with radiological evidence of pneumonia with pulmonary involvement above 50% and / or the presence of sepsis ( organ failure) or need for invasive mechanical ventilation.

inclusion criteria: - males and females aged > 18 years; - patients with flu syndrome (fever greater than 37.8c or feverish feeling referred by the patient associated with at least 1 respiratory symptom: cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose, signs cyanosis, flapping of the nose and dyspnoea); - diagnosis confirmed by real-time pcr or suspected covid-19; - hospitalized patients with: - moderate disease: hypoxemia with o2 saturation <93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute and / or radiological evidence of pneumonia with pulmonary impairment less than 50%; or - serious illness: hospitalized patients with hypoxemia with o2 saturation <93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute with radiological evidence of pneumonia with pulmonary involvement above 50% and / or the presence of sepsis ( organ failure) or need for invasive mechanical ventilation.

inclusion criteria: - males and females aged > 18 years; - patients with flu syndrome (fever greater than 37.8c or feverish feeling referred by the patient associated with at least 1 respiratory symptom: cough, difficulty breathing, sputum production, nasal or conjunctival congestion, difficulty swallowing, sore throat, runny nose, signs cyanosis, flapping of the nose and dyspnoea); - diagnosis confirmed by real-time pcr or suspected covid-19; - hospitalized patients with: - moderate disease: hypoxemia with o2 saturation <93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute and / or radiological evidence of pneumonia with pulmonary impairment less than 50%; or - serious illness: hospitalized patients with hypoxemia with o2 saturation <93% in room air and / or respiratory rate greater than or equal to 24 incursions per minute with radiological evidence of pneumonia with pulmonary involvement above 50% and / or the presence of sepsis ( organ failure) or need for invasive mechanical ventilation.