* history of hypersensitivity or allergy to any ingredient of the vaccine. * history of severe anaphylactic reaction. * history of seizures. * history of chronic diseases or cancer. * vaccination against sars-cov-2 with approved or experimental vaccines. * participation in any other study with an experimental intervention within the last 3 months. * administration of any other drug or herbal preparation within the last 30 days. * any vaccine administered within the last 30 days, including influenza vaccine. * fever at the time of entry. * blood transfusion or blood components transfusion within the last 4 months. * regular activity related to work, social interaction or entertainment that represents an exposure to sars-cov-2 higher than that of the general population, as per investigator judgement. * drug and alcohol abuse. * any medical or not medical condition that could interfere with patient safety, study compliance or data interpretation, as per investigator judgement.

* history of hypersensitivity or allergy to any ingredient of the vaccine. * history of severe anaphylactic reaction. * history of seizures. * history of chronic diseases or cancer. * vaccination against sars-cov-2 with approved or experimental vaccines. * participation in any other study with an experimental intervention within the last 3 months. * administration of any other drug or herbal preparation within the last 30 days. * any vaccine administered within the last 30 days, including influenza vaccine. * fever at the time of entry. * blood transfusion or blood components transfusion within the last 4 months. * regular activity related to work, social interaction or entertainment that represents an exposure to sars-cov-2 higher than that of the general population, as per investigator judgement. * drug and alcohol abuse. * any medical or not medical condition that could interfere with patient safety, study compliance or data interpretation, as per investigator judgement.

- history of hypersensitivity or allergy to any ingredient of the vaccine. - history of severe anaphylactic reaction. - history of seizures. - history of chronic diseases or cancer. - vaccination against sars-cov-2 with approved or experimental vaccines. - participation in any other study with an experimental intervention within the last 3 months. - administration of any other drug or herbal preparation within the last 30 days. - any vaccine administered within the last 30 days, including influenza vaccine. - fever at the time of entry. - blood transfusion or blood components transfusion within the last 4 months. - regular activity related to work, social interaction or entertainment that represents an exposure to sars-cov-2 higher than that of the general population, as per investigator judgement. - drug and alcohol abuse. - any medical or not medical condition that could interfere with patient safety, study compliance or data interpretation, as per investigator judgement.

- history of hypersensitivity or allergy to any ingredient of the vaccine. - history of severe anaphylactic reaction. - history of seizures. - history of chronic diseases or cancer. - vaccination against sars-cov-2 with approved or experimental vaccines. - participation in any other study with an experimental intervention within the last 3 months. - administration of any other drug or herbal preparation within the last 30 days. - any vaccine administered within the last 30 days, including influenza vaccine. - fever at the time of entry. - blood transfusion or blood components transfusion within the last 4 months. - regular activity related to work, social interaction or entertainment that represents an exposure to sars-cov-2 higher than that of the general population, as per investigator judgement. - drug and alcohol abuse. - any medical or not medical condition that could interfere with patient safety, study compliance or data interpretation, as per investigator judgement.