first dose exclusion criteria： * confirmed cases of sars-cov-2 infection, suspected cases, asymptomatic infections, or close contacts with the above population (check "china disease prevention and control information system"); * axillary body temperature is not less than 37.3℃ (older than 14 years) before vaccination, and axillary body temperature is not less than 37.5℃ (14 years or younger) before vaccination; * positive in sars-cov-2 igg and igm antibody screening; * have a history of sars virus infection (self-report, on-site inquiry); * fever (axillary temperature is not less than 37.3℃), dry cough, fatigue, nasal, congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, or dyspnea within 14 days before vaccination; * before vaccination, the results of blood biochemistry, blood routine, urine routine, and coagulation function related indexes are abnormal, which exceed the reference value range, and have clinical significance abnormalities (only refers to phase i); * previous severe allergic reaction to vaccination (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain); * allergic to any component of the study vaccine (such as aluminum, histidine, etc.); * have a history of convulsions, epilepsy, encephalopathy, long-term alcoholism and drug abuse, thyroidectomy, infectious diseases, mental illness or family history; * congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc; * known or suspected diseases include: severe respiratory disease, severe liver and kidney disease, severe cardiovascular disease, drug-uncontrollable hypertension (systolic blood pressure is not less than 140mmhg, diastolic blood pressure is not less than 90mmhg), high blood glucose, diabetic complications , malignant tumors, various acute diseases or acute attacks of chronic diseases; * have been diagnosed with congenital or acquired immunodeficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases; * have a history of abnormal coagulation function (such as coagulation factor deficiency, coagulopathy); * asthenia or splenectomy, functional asthenia caused by any situation; * are receiving anti-tb (tuberculosis) treatment; * have received immune enhancement or inhibitor therapy within 3 months (continuous oral or instillation for more than 14 days); * have received a live attenuated vaccine within 28 days before vaccination, or received other vaccines within 14 days before vaccination; * have received blood products within 3 months before vaccination; * have received other study drugs within 6 months before vaccination; * plan to move before the end of the study or leave the local area for a long time during the scheduled study visit; * other conditions considered by the investigator to be inappropriate for participation in the study. exclusion criteria for the second and third doses of vaccination * positive urine pregnancy test; * have a high fever (axillary temperature is not less than 39.0℃) for three days and severe allergic reaction after the previous dose of vaccination; * severe adverse reactions that are causally related to the previous dose of vaccination; * for those newly discovered or newly identified after the previous dose of vaccine that does not meet the first dose selection criteria or meets the first dose exclusion criteria, the investigator will determine whether to continue participating in the study; * other exclusion reasons considered by the investigator.

first dose exclusion criteria： * confirmed cases of sars-cov-2 infection, suspected cases, asymptomatic infections, or close contacts with the above population (check "china disease prevention and control information system"); * axillary body temperature is not less than 37.3℃ (older than 14 years) before vaccination, and axillary body temperature is not less than 37.5℃ (14 years or younger) before vaccination; * positive in sars-cov-2 igg and igm antibody screening; * have a history of sars virus infection (self-report, on-site inquiry); * fever (axillary temperature is not less than 37.3℃), dry cough, fatigue, nasal, congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, or dyspnea within 14 days before vaccination; * before vaccination, the results of blood biochemistry, blood routine, urine routine, and coagulation function related indexes are abnormal, which exceed the reference value range, and have clinical significance abnormalities (only refers to phase i); * previous severe allergic reaction to vaccination (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain); * allergic to any component of the study vaccine (such as aluminum, histidine, etc.); * have a history of convulsions, epilepsy, encephalopathy, long-term alcoholism and drug abuse, thyroidectomy, infectious diseases, mental illness or family history; * congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc; * known or suspected diseases include: severe respiratory disease, severe liver and kidney disease, severe cardiovascular disease, drug-uncontrollable hypertension (systolic blood pressure is not less than 140mmhg, diastolic blood pressure is not less than 90mmhg), high blood glucose, diabetic complications , malignant tumors, various acute diseases or acute attacks of chronic diseases; * have been diagnosed with congenital or acquired immunodeficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases; * have a history of abnormal coagulation function (such as coagulation factor deficiency, coagulopathy); * asthenia or splenectomy, functional asthenia caused by any situation; * are receiving anti-tb (tuberculosis) treatment; * have received immune enhancement or inhibitor therapy within 3 months (continuous oral or instillation for more than 14 days); * have received a live attenuated vaccine within 28 days before vaccination, or received other vaccines within 14 days before vaccination; * have received blood products within 3 months before vaccination; * have received other study drugs within 6 months before vaccination; * plan to move before the end of the study or leave the local area for a long time during the scheduled study visit; * other conditions considered by the investigator to be inappropriate for participation in the study. exclusion criteria for the second and third doses of vaccination * positive urine pregnancy test; * have a high fever (axillary temperature is not less than 39.0℃) for three days and severe allergic reaction after the previous dose of vaccination; * severe adverse reactions that are causally related to the previous dose of vaccination; * for those newly discovered or newly identified after the previous dose of vaccine that does not meet the first dose selection criteria or meets the first dose exclusion criteria, the investigator will determine whether to continue participating in the study; * other exclusion reasons considered by the investigator.

first dose exclusion criteria： - confirmed cases of sars-cov-2 infection, suspected cases, asymptomatic infections, or close contacts with the above population (check "china disease prevention and control information system"); - axillary body temperature is not less than 37.3℃ (older than 14 years) before vaccination, and axillary body temperature is not less than 37.5℃ (14 years or younger) before vaccination; - positive in sars-cov-2 igg and igm antibody screening; - have a history of sars virus infection (self-report, on-site inquiry); - fever (axillary temperature is not less than 37.3℃), dry cough, fatigue, nasal, congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, or dyspnea within 14 days before vaccination; - before vaccination, the results of blood biochemistry, blood routine, urine routine, and coagulation function related indexes are abnormal, which exceed the reference value range, and have clinical significance abnormalities (only refers to phase i); - previous severe allergic reaction to vaccination (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain); - allergic to any component of the study vaccine (such as aluminum, histidine, etc.); - have a history of convulsions, epilepsy, encephalopathy, long-term alcoholism and drug abuse, thyroidectomy, infectious diseases, mental illness or family history; - congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc; - known or suspected diseases include: severe respiratory disease, severe liver and kidney disease, severe cardiovascular disease, drug-uncontrollable hypertension (systolic blood pressure is not less than 140mmhg, diastolic blood pressure is not less than 90mmhg), high blood glucose, diabetic complications , malignant tumors, various acute diseases or acute attacks of chronic diseases; - have been diagnosed with congenital or acquired immunodeficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases; - have a history of abnormal coagulation function (such as coagulation factor deficiency, coagulopathy); - asthenia or splenectomy, functional asthenia caused by any situation; - are receiving anti-tb (tuberculosis) treatment; - have received immune enhancement or inhibitor therapy within 3 months (continuous oral or instillation for more than 14 days); - have received a live attenuated vaccine within 28 days before vaccination, or received other vaccines within 14 days before vaccination; - have received blood products within 3 months before vaccination; - have received other study drugs within 6 months before vaccination; - plan to move before the end of the study or leave the local area for a long time during the scheduled study visit; - other conditions considered by the investigator to be inappropriate for participation in the study. exclusion criteria for the second and third doses of vaccination - positive urine pregnancy test; - have a high fever (axillary temperature is not less than 39.0℃) for three days and severe allergic reaction after the previous dose of vaccination; - severe adverse reactions that are causally related to the previous dose of vaccination; - for those newly discovered or newly identified after the previous dose of vaccine that does not meet the first dose selection criteria or meets the first dose exclusion criteria, the investigator will determine whether to continue participating in the study; - other exclusion reasons considered by the investigator.

first dose exclusion criteria： - confirmed cases of sars-cov-2 infection, suspected cases, asymptomatic infections, or close contacts with the above population (check "china disease prevention and control information system"); - axillary body temperature is not less than 37.3℃ (older than 14 years) before vaccination, and axillary body temperature is not less than 37.5℃ (14 years or younger) before vaccination; - positive in sars-cov-2 igg and igm antibody screening; - have a history of sars virus infection (self-report, on-site inquiry); - fever (axillary temperature is not less than 37.3℃), dry cough, fatigue, nasal, congestion, runny nose, sore throat, myalgia, diarrhea, shortness of breath, or dyspnea within 14 days before vaccination; - before vaccination, the results of blood biochemistry, blood routine, urine routine, and coagulation function related indexes are abnormal, which exceed the reference value range, and have clinical significance abnormalities (only refers to phase i); - previous severe allergic reaction to vaccination (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema or abdominal pain); - allergic to any component of the study vaccine (such as aluminum, histidine, etc.); - have a history of convulsions, epilepsy, encephalopathy, long-term alcoholism and drug abuse, thyroidectomy, infectious diseases, mental illness or family history; - congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc; - known or suspected diseases include: severe respiratory disease, severe liver and kidney disease, severe cardiovascular disease, drug-uncontrollable hypertension (systolic blood pressure is not less than 140mmhg, diastolic blood pressure is not less than 90mmhg), high blood glucose, diabetic complications , malignant tumors, various acute diseases or acute attacks of chronic diseases; - have been diagnosed with congenital or acquired immunodeficiency, hiv infection, lymphoma, leukemia or other autoimmune diseases; - have a history of abnormal coagulation function (such as coagulation factor deficiency, coagulopathy); - asthenia or splenectomy, functional asthenia caused by any situation; - are receiving anti-tb (tuberculosis) treatment; - have received immune enhancement or inhibitor therapy within 3 months (continuous oral or instillation for more than 14 days); - have received a live attenuated vaccine within 28 days before vaccination, or received other vaccines within 14 days before vaccination; - have received blood products within 3 months before vaccination; - have received other study drugs within 6 months before vaccination; - plan to move before the end of the study or leave the local area for a long time during the scheduled study visit; - other conditions considered by the investigator to be inappropriate for participation in the study. exclusion criteria for the second and third doses of vaccination - positive urine pregnancy test; - have a high fever (axillary temperature is not less than 39.0℃) for three days and severe allergic reaction after the previous dose of vaccination; - severe adverse reactions that are causally related to the previous dose of vaccination; - for those newly discovered or newly identified after the previous dose of vaccine that does not meet the first dose selection criteria or meets the first dose exclusion criteria, the investigator will determine whether to continue participating in the study; - other exclusion reasons considered by the investigator.