participants with any of the following criteria will be excluded: 1. history of seizure, encephalopathy, or psychosis, 2. history of allergic reactions to any known vaccine or to any component of the study vaccine, 3. pregnant, breastfeeding, or positive pregnancy test or planning to conceive within 6 months, 4. history of sars-cov-2 infection, 5. severe cardiovascular disorders (arrhythmia, conduction disorders, history of myocardial infarction, uncontrolled hypertension), 6. severe chronic disorders (asthma, diabetes mellitus, thyroid disorders...etc), 7. congenital or acquired angioedema, 8. diagnosis of immunodeficiency, 9. diagnosis of bleeding diathesis, 10. use of immunosuppressive treatment, anti-allergic treatment, cytotoxic treatment, inhaler corticosteroids (allergic rhinitis or topical steroid ointments are excluded), 11. those who received blood and blood product transfusions in the last 6 months, 12. those on any vaccine program or experimental medication within 1 month prior to the study, 13. history of any vaccination against sars-cov-2 within 1 month prior to the study, 14. use of active tuberculosis treatment, 15. history of addictive drug use, 16. history of alcohol abuse and/or history of alcohol intake more than 2 units per day or 10 units per week and/or positive breath alcohol test (one unit of alcohol equals to 250 ml beer, 125 ml wine or 25 ml whiskey), 17. according to the investigator's evaluation, those who have any condition (medical, psychological, social, etc.) that may impair the patient's compliance with the study will be excluded from the study.

participants with any of the following criteria will be excluded: 1. history of seizure, encephalopathy, or psychosis, 2. history of allergic reactions to any known vaccine or to any component of the study vaccine, 3. pregnant, breastfeeding, or positive pregnancy test or planning to conceive within 6 months, 4. history of sars-cov-2 infection, 5. severe cardiovascular disorders (arrhythmia, conduction disorders, history of myocardial infarction, uncontrolled hypertension), 6. severe chronic disorders (asthma, diabetes mellitus, thyroid disorders...etc), 7. congenital or acquired angioedema, 8. diagnosis of immunodeficiency, 9. diagnosis of bleeding diathesis, 10. use of immunosuppressive treatment, anti-allergic treatment, cytotoxic treatment, inhaler corticosteroids (allergic rhinitis or topical steroid ointments are excluded), 11. those who received blood and blood product transfusions in the last 6 months, 12. those on any vaccine program or experimental medication within 1 month prior to the study, 13. history of any vaccination against sars-cov-2 within 1 month prior to the study, 14. use of active tuberculosis treatment, 15. history of addictive drug use, 16. history of alcohol abuse and/or history of alcohol intake more than 2 units per day or 10 units per week and/or positive breath alcohol test (one unit of alcohol equals to 250 ml beer, 125 ml wine or 25 ml whiskey), 17. according to the investigator's evaluation, those who have any condition (medical, psychological, social, etc.) that may impair the patient's compliance with the study will be excluded from the study.

participants with any of the following criteria will be excluded: history of seizure, encephalopathy, or psychosis, history of allergic reactions to any known vaccine or to any component of the study vaccine, pregnant, breastfeeding, or positive pregnancy test or planning to conceive within 6 months, history of sars-cov-2 infection, severe cardiovascular disorders (arrhythmia, conduction disorders, history of myocardial infarction, uncontrolled hypertension), severe chronic disorders (asthma, diabetes mellitus, thyroid disorders…etc), congenital or acquired angioedema, diagnosis of immunodeficiency, diagnosis of bleeding diathesis, use of immunosuppressive treatment, anti-allergic treatment, cytotoxic treatment, inhaler corticosteroids (allergic rhinitis or topical steroid ointments are excluded), those who received blood and blood product transfusions in the last 6 months, those on any vaccine program or experimental medication within 1 month prior to the study, history of any vaccination against sars-cov-2 within 1 month prior to the study, use of active tuberculosis treatment, history of addictive drug use, history of alcohol abuse and/or history of alcohol intake more than 2 units per day or 10 units per week and/or positive breath alcohol test (one unit of alcohol equals to 250 ml beer, 125 ml wine or 25 ml whiskey), according to the investigator's evaluation, those who have any condition (medical, psychological, social, etc.) that may impair the patient's compliance with the study will be excluded from the study.

participants with any of the following criteria will be excluded: history of seizure, encephalopathy, or psychosis, history of allergic reactions to any known vaccine or to any component of the study vaccine, pregnant, breastfeeding, or positive pregnancy test or planning to conceive within 6 months, history of sars-cov-2 infection, severe cardiovascular disorders (arrhythmia, conduction disorders, history of myocardial infarction, uncontrolled hypertension), severe chronic disorders (asthma, diabetes mellitus, thyroid disorders…etc), congenital or acquired angioedema, diagnosis of immunodeficiency, diagnosis of bleeding diathesis, use of immunosuppressive treatment, anti-allergic treatment, cytotoxic treatment, inhaler corticosteroids (allergic rhinitis or topical steroid ointments are excluded), those who received blood and blood product transfusions in the last 6 months, those on any vaccine program or experimental medication within 1 month prior to the study, history of any vaccination against sars-cov-2 within 1 month prior to the study, use of active tuberculosis treatment, history of addictive drug use, history of alcohol abuse and/or history of alcohol intake more than 2 units per day or 10 units per week and/or positive breath alcohol test (one unit of alcohol equals to 250 ml beer, 125 ml wine or 25 ml whiskey), according to the investigator's evaluation, those who have any condition (medical, psychological, social, etc.) that may impair the patient's compliance with the study will be excluded from the study.

participants with any of the following criteria will be excluded: 1. history of seizure, encephalopathy, or psychosis, 2. history of allergic reactions to any known vaccine or to any component of the study vaccine, 3. pregnant, breastfeeding, or positive pregnancy test or planning to conceive within 6 months, 4. history of sars-cov-2 infection, 5. severe cardiovascular disorders (arrhythmia, conduction disorders, history of myocardial infarction, uncontrolled hypertension), 6. severe chronic disorders (asthma, diabetes mellitus, thyroid disorders…etc), 7. congenital or acquired angioedema, 8. diagnosis of immunodeficiency, 9. diagnosis of bleeding diathesis, 10. use of immunosuppressive treatment, anti-allergic treatment, cytotoxic treatment, inhaler corticosteroids (allergic rhinitis or topical steroid ointments are excluded), 11. those who received blood and blood product transfusions in the last 6 months, 12. those on any vaccine program or experimental medication within 1 month prior to the study, 13. history of any vaccination against sars-cov-2 within 1 month prior to the study, 14. use of active tuberculosis treatment, 15. history of addictive drug use, 16. history of alcohol abuse and/or history of alcohol intake more than 2 units per day or 10 units per week and/or positive breath alcohol test (one unit of alcohol equals to 250 ml beer, 125 ml wine or 25 ml whiskey), 17. according to the investigator's evaluation, those who have any condition (medical, psychological, social, etc.) that may impair the patient's compliance with the study will be excluded from the study.

participants with any of the following criteria will be excluded: 1. history of seizure, encephalopathy, or psychosis, 2. history of allergic reactions to any known vaccine or to any component of the study vaccine, 3. pregnant, breastfeeding, or positive pregnancy test or planning to conceive within 6 months, 4. history of sars-cov-2 infection, 5. severe cardiovascular disorders (arrhythmia, conduction disorders, history of myocardial infarction, uncontrolled hypertension), 6. severe chronic disorders (asthma, diabetes mellitus, thyroid disorders…etc), 7. congenital or acquired angioedema, 8. diagnosis of immunodeficiency, 9. diagnosis of bleeding diathesis, 10. use of immunosuppressive treatment, anti-allergic treatment, cytotoxic treatment, inhaler corticosteroids (allergic rhinitis or topical steroid ointments are excluded), 11. those who received blood and blood product transfusions in the last 6 months, 12. those on any vaccine program or experimental medication within 1 month prior to the study, 13. history of any vaccination against sars-cov-2 within 1 month prior to the study, 14. use of active tuberculosis treatment, 15. history of addictive drug use, 16. history of alcohol abuse and/or history of alcohol intake more than 2 units per day or 10 units per week and/or positive breath alcohol test (one unit of alcohol equals to 250 ml beer, 125 ml wine or 25 ml whiskey), 17. according to the investigator's evaluation, those who have any condition (medical, psychological, social, etc.) that may impair the patient's compliance with the study will be excluded from the study.