* no consent/inability to obtain consent * rockwood clinical frailty score \> 4 * moribund patient not expected to survive 24 hours * any other irreversible disease or condition for which 6-month mortality is estimated to be greater than 50% * currently receiving extracorporeal life support * pregnant or lactating * patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * moderate to severe chronic liver disease (childs-pugh score \> 12) * severe chronic respiratory disease with a baseline paco2 \> 50 mm hg or the use of home oxygen * documented deep venous thrombosis or pulmonary embolism within the preceding 3 months * inability/contra-indications to receiving local standard of care thromboprophylaxis * chronic immunosuppression (any chronic immunotherapy including daily oral steroid use \>6months) * known hiv, hep b/c positive, or active tuberculosis * multisystem shock (sofa score change from baseline of \>2 in \>2 systems) * patient, surrogate, or physician not committed to full support including intubation (exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)

* no consent/inability to obtain consent * rockwood clinical frailty score \> 4 * moribund patient not expected to survive 24 hours * any other irreversible disease or condition for which 6-month mortality is estimated to be greater than 50% * currently receiving extracorporeal life support * pregnant or lactating * patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * moderate to severe chronic liver disease (childs-pugh score \> 12) * severe chronic respiratory disease with a baseline paco2 \> 50 mm hg or the use of home oxygen * documented deep venous thrombosis or pulmonary embolism within the preceding 3 months * inability/contra-indications to receiving local standard of care thromboprophylaxis * chronic immunosuppression (any chronic immunotherapy including daily oral steroid use \>6months) * known hiv, hep b/c positive, or active tuberculosis * multisystem shock (sofa score change from baseline of \>2 in \>2 systems) * patient, surrogate, or physician not committed to full support including intubation (exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)

- no consent/inability to obtain consent - rockwood clinical frailty score > 4 - moribund patient not expected to survive 24 hours - any other irreversible disease or condition for which 6-month mortality is estimated to be greater than 50% - currently receiving extracorporeal life support - pregnant or lactating - patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial - moderate to severe chronic liver disease (childs-pugh score > 12) - severe chronic respiratory disease with a baseline paco2 > 50 mm hg or the use of home oxygen - documented deep venous thrombosis or pulmonary embolism within the preceding 3 months - inability/contra-indications to receiving local standard of care thromboprophylaxis - chronic immunosuppression (any chronic immunotherapy including daily oral steroid use >6months) - known hiv, hep b/c positive, or active tuberculosis - multisystem shock (sofa score change from baseline of >2 in >2 systems) - patient, surrogate, or physician not committed to full support including intubation (exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)

- no consent/inability to obtain consent - rockwood clinical frailty score > 4 - moribund patient not expected to survive 24 hours - any other irreversible disease or condition for which 6-month mortality is estimated to be greater than 50% - currently receiving extracorporeal life support - pregnant or lactating - patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial - moderate to severe chronic liver disease (childs-pugh score > 12) - severe chronic respiratory disease with a baseline paco2 > 50 mm hg or the use of home oxygen - documented deep venous thrombosis or pulmonary embolism within the preceding 3 months - inability/contra-indications to receiving local standard of care thromboprophylaxis - chronic immunosuppression (any chronic immunotherapy including daily oral steroid use >6months) - known hiv, hep b/c positive, or active tuberculosis - multisystem shock (sofa score change from baseline of >2 in >2 systems) - patient, surrogate, or physician not committed to full support including intubation (exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)