inclusion criteria: 1. male or female adult ≥ 18 years of age at time of enrollment 2. laboratory confirmed sars-cov-2 infection determined by pcr within 14 days prior to randomization and no alternative explanation for current clinical condition 3. moderate or severe ards (pao2:fio2 ratio ≤ 200mmhg) requiring mechanical ventilation within 7 days prior to randomization 4. hyper-inflammatory ards sub-phenotype defined as any one of the following: 1. c-reactive protein (crp) \> 100mg/dl 2. d-dimer \> 600ng/ml 3. il-6 \> 10pg/ml 5. willing and/or able to comply with study-related procedures and assessments 6. provide informed consent signed by study patient or legally acceptable representative

inclusion criteria: 1. male or female adult ≥ 18 years of age at time of enrollment 2. laboratory confirmed sars-cov-2 infection determined by pcr within 14 days prior to randomization and no alternative explanation for current clinical condition 3. moderate or severe ards (pao2:fio2 ratio ≤ 200mmhg) requiring mechanical ventilation within 7 days prior to randomization 4. hyper-inflammatory ards sub-phenotype defined as any one of the following: 1. c-reactive protein (crp) \> 100mg/dl 2. d-dimer \> 600ng/ml 3. il-6 \> 10pg/ml 5. willing and/or able to comply with study-related procedures and assessments 6. provide informed consent signed by study patient or legally acceptable representative

inclusion criteria: male or female adult ≥ 18 years of age at time of enrollment laboratory confirmed sars-cov-2 infection determined by pcr within 14 days prior to randomization and no alternative explanation for current clinical condition moderate or severe ards (pao2:fio2 ratio ≤ 200mmhg) requiring mechanical ventilation within 7 days prior to randomization hyper-inflammatory ards sub-phenotype defined as any one of the following: c-reactive protein (crp) > 100mg/dl d-dimer > 600ng/ml il-6 > 10pg/ml willing and/or able to comply with study-related procedures and assessments provide informed consent signed by study patient or legally acceptable representative

inclusion criteria: male or female adult ≥ 18 years of age at time of enrollment laboratory confirmed sars-cov-2 infection determined by pcr within 14 days prior to randomization and no alternative explanation for current clinical condition moderate or severe ards (pao2:fio2 ratio ≤ 200mmhg) requiring mechanical ventilation within 7 days prior to randomization hyper-inflammatory ards sub-phenotype defined as any one of the following: c-reactive protein (crp) > 100mg/dl d-dimer > 600ng/ml il-6 > 10pg/ml willing and/or able to comply with study-related procedures and assessments provide informed consent signed by study patient or legally acceptable representative

inclusion criteria: 1. male or female adult ≥ 18 years of age at time of enrollment 2. laboratory confirmed sars-cov-2 infection determined by pcr within 14 days prior to randomization and no alternative explanation for current clinical condition 3. moderate or severe ards (pao2:fio2 ratio ≤ 200mmhg) requiring mechanical ventilation within 7 days prior to randomization 4. hyper-inflammatory ards sub-phenotype defined as any one of the following: 1. c-reactive protein (crp) > 100mg/dl 2. d-dimer > 600ng/ml 3. il-6 > 10pg/ml 5. willing and/or able to comply with study-related procedures and assessments 6. provide informed consent signed by study patient or legally acceptable representative

inclusion criteria: 1. male or female adult ≥ 18 years of age at time of enrollment 2. laboratory confirmed sars-cov-2 infection determined by pcr within 14 days prior to randomization and no alternative explanation for current clinical condition 3. moderate or severe ards (pao2:fio2 ratio ≤ 200mmhg) requiring mechanical ventilation within 7 days prior to randomization 4. hyper-inflammatory ards sub-phenotype defined as any one of the following: 1. c-reactive protein (crp) > 100mg/dl 2. d-dimer > 600ng/ml 3. il-6 > 10pg/ml 5. willing and/or able to comply with study-related procedures and assessments 6. provide informed consent signed by study patient or legally acceptable representative