* 1. pregnancy or breastfeeding * 2. known hiv, hbv or hcv infection * 3. patients with malignant tumor, other serious systemic diseases and psychosis * 4. patients who are participating in other clinical trials * 5. inability to provide informed consent or to comply with test requirements

* 1. pregnancy or breastfeeding * 2. known hiv, hbv or hcv infection * 3. patients with malignant tumor, other serious systemic diseases and psychosis * 4. patients who are participating in other clinical trials * 5. inability to provide informed consent or to comply with test requirements

- 1. pregnancy or breastfeeding - 2. known hiv, hbv or hcv infection - 3. patients with malignant tumor, other serious systemic diseases and psychosis - 4. patients who are participating in other clinical trials - 5. inability to provide informed consent or to comply with test requirements

- 1. pregnancy or breastfeeding - 2. known hiv, hbv or hcv infection - 3. patients with malignant tumor, other serious systemic diseases and psychosis - 4. patients who are participating in other clinical trials - 5. inability to provide informed consent or to comply with test requirements