1. respiratory rate \>30 rpm, so2 \<93%, pao2/fio2 \<200 despite intervention with oxygen therapy after 60 minutes of hospitalization. 2. new alteration of the state of alert that does not revert after interventions 60 minutes after admission to hospital. 3. pam ≤ 65mmhg despite initial resuscitation on arrival at the centre. 4. pregnant or breastfeeding patients. 5. patients that the investigators consider inappropriate to participate in the clinical trial 6. contraindication to transfusion or history of previous severe reaction to blood products. 7. have received any blood products in the last 120 days.

1. respiratory rate \>30 rpm, so2 \<93%, pao2/fio2 \<200 despite intervention with oxygen therapy after 60 minutes of hospitalization. 2. new alteration of the state of alert that does not revert after interventions 60 minutes after admission to hospital. 3. pam ≤ 65mmhg despite initial resuscitation on arrival at the centre. 4. pregnant or breastfeeding patients. 5. patients that the investigators consider inappropriate to participate in the clinical trial 6. contraindication to transfusion or history of previous severe reaction to blood products. 7. have received any blood products in the last 120 days.

respiratory rate >30 rpm, so2 <93%, pao2/fio2 <200 despite intervention with oxygen therapy after 60 minutes of hospitalization. new alteration of the state of alert that does not revert after interventions 60 minutes after admission to hospital. pam ≤ 65mmhg despite initial resuscitation on arrival at the centre. pregnant or breastfeeding patients. patients that the investigators consider inappropriate to participate in the clinical trial contraindication to transfusion or history of previous severe reaction to blood products. have received any blood products in the last 120 days.

respiratory rate >30 rpm, so2 <93%, pao2/fio2 <200 despite intervention with oxygen therapy after 60 minutes of hospitalization. new alteration of the state of alert that does not revert after interventions 60 minutes after admission to hospital. pam ≤ 65mmhg despite initial resuscitation on arrival at the centre. pregnant or breastfeeding patients. patients that the investigators consider inappropriate to participate in the clinical trial contraindication to transfusion or history of previous severe reaction to blood products. have received any blood products in the last 120 days.

1. respiratory rate >30 rpm, so2 <93%, pao2/fio2 <200 despite intervention with oxygen therapy after 60 minutes of hospitalization. 2. new alteration of the state of alert that does not revert after interventions 60 minutes after admission to hospital. 3. pam ≤ 65mmhg despite initial resuscitation on arrival at the centre. 4. pregnant or breastfeeding patients. 5. patients that the investigators consider inappropriate to participate in the clinical trial 6. contraindication to transfusion or history of previous severe reaction to blood products. 7. have received any blood products in the last 120 days.

1. respiratory rate >30 rpm, so2 <93%, pao2/fio2 <200 despite intervention with oxygen therapy after 60 minutes of hospitalization. 2. new alteration of the state of alert that does not revert after interventions 60 minutes after admission to hospital. 3. pam ≤ 65mmhg despite initial resuscitation on arrival at the centre. 4. pregnant or breastfeeding patients. 5. patients that the investigators consider inappropriate to participate in the clinical trial 6. contraindication to transfusion or history of previous severe reaction to blood products. 7. have received any blood products in the last 120 days.