* previous history of ards in the last month * chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance * history of organ allograft. * active cancer * liver cirrhosis with basal child and pugh of c * pulmonary fibrosis * patient with end-of-life decision * patient not expected to survive for 24 hours * woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test * patient already enrolled in another interventional pharmacotherapy protocol on covid-19 * patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients * presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 1.5x109/l, ast or alt greater than 5 x uln, platelets \<50,000 per mm3 * use of chronic oral corticosteroids \> 10 mg prednisone equivalent a day for a non-covid-19-related condition * current uncontrolled autoimmune disease * patients with uncontrolled suspected or known active systemic bacterial or fungal infections * patient with severe, uncontrolled pre-existing (chronic) organ failure (myocardial, hepatic or renal) * vaccination with live attenuated vaccines in the month preceding the inclusion * patient with burns to ≥ 15% of their total body surface area * patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support * patient under legal protection (protection of the court, or in curatorship or guardianship).

* previous history of ards in the last month * chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance * history of organ allograft. * active cancer * liver cirrhosis with basal child and pugh of c * pulmonary fibrosis * patient with end-of-life decision * patient not expected to survive for 24 hours * woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test * patient already enrolled in another interventional pharmacotherapy protocol on covid-19 * patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients * presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 1.5x109/l, ast or alt greater than 5 x uln, platelets \<50,000 per mm3 * use of chronic oral corticosteroids \> 10 mg prednisone equivalent a day for a non-covid-19-related condition * current uncontrolled autoimmune disease * patients with uncontrolled suspected or known active systemic bacterial or fungal infections * patient with severe, uncontrolled pre-existing (chronic) organ failure (myocardial, hepatic or renal) * vaccination with live attenuated vaccines in the month preceding the inclusion * patient with burns to ≥ 15% of their total body surface area * patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support * patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - history of organ allograft. - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 1.5x109/l, ast or alt greater than 5 x uln, platelets <50,000 per mm3 - use of chronic oral corticosteroids > 10 mg prednisone equivalent a day for a non-covid-19-related condition - current uncontrolled autoimmune disease - patients with uncontrolled suspected or known active systemic bacterial or fungal infections - patient with severe, uncontrolled pre-existing (chronic) organ failure (myocardial, hepatic or renal) - vaccination with live attenuated vaccines in the month preceding the inclusion - patient with burns to ≥ 15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - history of organ allograft. - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (anc) less than 1.5x109/l, ast or alt greater than 5 x uln, platelets <50,000 per mm3 - use of chronic oral corticosteroids > 10 mg prednisone equivalent a day for a non-covid-19-related condition - current uncontrolled autoimmune disease - patients with uncontrolled suspected or known active systemic bacterial or fungal infections - patient with severe, uncontrolled pre-existing (chronic) organ failure (myocardial, hepatic or renal) - vaccination with live attenuated vaccines in the month preceding the inclusion - patient with burns to ≥ 15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - allogeneic bone marrow transplantation - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol - on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - patient with burns to ≥15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).

- previous history of ards in the last month - chronic respiratory diseases requiring long-term oxygen therapy and/or long-term respiratory assistance - allogeneic bone marrow transplantation - active cancer - liver cirrhosis with basal child and pugh of c - pulmonary fibrosis - patient with end-of-life decision - patient not expected to survive for 24 hours - woman known to be pregnant, lactating or with a positive (urine or serum test) or indeterminate (serum test) pregnancy test - patient already enrolled in another interventional pharmacotherapy protocol - on covid-19 - patient with known hypersensitivity to natural or recombinant interleukin-2 or to any of the excipients - patient with burns to ≥15% of their total body surface area - patient receiving extra-corporeal membrane oxygenation, high-frequency oscillatory ventilation or any form of extra-corporeal lung support - patient under legal protection (protection of the court, or in curatorship or guardianship).