inclusion criteria: * sars-cov-2 infection (positive testing) or computed tomography (ct) scan-suspected covid-19 ards * male and female patients, age 18 to 85 years * icu patients with ards defined as pao2/fio2 \< 200mmhg (=26.6kpa) * time of intubation not longer than 24 hours * qtc time (ecg) not longer than 470 ms ♂ (male)/ 480 ms ♀ (female) * sedation and mechanical ventilation in icu * informed consent, signed by a representative or by an independent physician

inclusion criteria: * sars-cov-2 infection (positive testing) or computed tomography (ct) scan-suspected covid-19 ards * male and female patients, age 18 to 85 years * icu patients with ards defined as pao2/fio2 \< 200mmhg (=26.6kpa) * time of intubation not longer than 24 hours * qtc time (ecg) not longer than 470 ms ♂ (male)/ 480 ms ♀ (female) * sedation and mechanical ventilation in icu * informed consent, signed by a representative or by an independent physician

inclusion criteria: - sars-cov-2 infection (positive testing) or computed tomography (ct) scan-suspected covid-19 ards - male and female patients, age 18 to 85 years - icu patients with ards defined as pao2/fio2 < 200mmhg (=26.6kpa) - time of intubation not longer than 24 hours - qtc time (ecg) not longer than 470 ms ♂ (male)/ 480 ms ♀ (female) - sedation and mechanical ventilation in icu - informed consent, signed by a representative or by an independent physician

inclusion criteria: - sars-cov-2 infection (positive testing) or computed tomography (ct) scan-suspected covid-19 ards - male and female patients, age 18 to 85 years - icu patients with ards defined as pao2/fio2 < 200mmhg (=26.6kpa) - time of intubation not longer than 24 hours - qtc time (ecg) not longer than 470 ms ♂ (male)/ 480 ms ♀ (female) - sedation and mechanical ventilation in icu - informed consent, signed by a representative or by an independent physician

inclusion criteria: - sars-cov-2 infection (positive testing) or computed tomography (ct) scan-suspected covid-19 ards - male and female patients, age 18 to 85 years - icu patients with ards defined as pao2/fio2 < 200mmhg (=26.6kpa) - time of intubation not longer than 24 hours - sedation and mechanical ventilation in icu - informed consent, signed by a representative or by an independent physician

inclusion criteria: - sars-cov-2 infection (positive testing) or computed tomography (ct) scan-suspected covid-19 ards - male and female patients, age 18 to 85 years - icu patients with ards defined as pao2/fio2 < 200mmhg (=26.6kpa) - time of intubation not longer than 24 hours - sedation and mechanical ventilation in icu - informed consent, signed by a representative or by an independent physician