* pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes: * intrauterine devices (iud), contraceptive implants, or tubal sterilization * hormone methods with a barrier method * two barrier methods * if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction * co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein (p-gp) transport system inhibitors * concurrent use of strong cyp3a4 or p-gp inhibitors in patients with renal or hepatic impairment; * severe hematologic or neuromuscular disorders * severe renal impairment with concomitant hepatic impairment

* pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes: * intrauterine devices (iud), contraceptive implants, or tubal sterilization * hormone methods with a barrier method * two barrier methods * if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction * co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein (p-gp) transport system inhibitors * concurrent use of strong cyp3a4 or p-gp inhibitors in patients with renal or hepatic impairment; * severe hematologic or neuromuscular disorders * severe renal impairment with concomitant hepatic impairment

pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes: intrauterine devices (iud), contraceptive implants, or tubal sterilization hormone methods with a barrier method two barrier methods if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein (p-gp) transport system inhibitors concurrent use of strong cyp3a4 or p-gp inhibitors in patients with renal or hepatic impairment; severe hematologic or neuromuscular disorders severe renal impairment with concomitant hepatic impairment

pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes: intrauterine devices (iud), contraceptive implants, or tubal sterilization hormone methods with a barrier method two barrier methods if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction co-administration of cytochrome p450 3a4 (cypa3a4) and p-glycoprotein (p-gp) transport system inhibitors concurrent use of strong cyp3a4 or p-gp inhibitors in patients with renal or hepatic impairment; severe hematologic or neuromuscular disorders severe renal impairment with concomitant hepatic impairment

- pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes: - intrauterine devices (iud), contraceptive implants, or tubal sterilization - hormone methods with a barrier method - two barrier methods - if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction - co-administration of cypa3a4 and p-glycoprotein (p-gp) transport system inhibitors - concurrent use of strong cyp3a4 or p-gp inhibitors in patients with renal or hepatic impairment; - severe hematologic or neuaromuscular disorders - severe renal impairmant with concomitant hepatic impairment

- pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes: - intrauterine devices (iud), contraceptive implants, or tubal sterilization - hormone methods with a barrier method - two barrier methods - if a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction - co-administration of cypa3a4 and p-glycoprotein (p-gp) transport system inhibitors - concurrent use of strong cyp3a4 or p-gp inhibitors in patients with renal or hepatic impairment; - severe hematologic or neuaromuscular disorders - severe renal impairmant with concomitant hepatic impairment