* women capable of bearing children as well as pregnant and breastfeeding women * participant in another interventional trail * at screening visit, no oral medication intake possible * advanced heart failure nyha stage iii-iv * left ventricular ejection fraction \<30% or ntprobnp ≥600pg/ml in case of clinical signs of heart failure * acute coronary syndrome ≤ 3 months * severe arterial hypertension (concomitant use of more than 4 different antihypertensive drug classes) * acute respiratory distress syndrome with need for mechanical ventilation * patients who at not capable of home blood pressure monitoring * patients who cannot be switched to an alternative medication

* women capable of bearing children as well as pregnant and breastfeeding women * participant in another interventional trail * at screening visit, no oral medication intake possible * advanced heart failure nyha stage iii-iv * left ventricular ejection fraction \<30% or ntprobnp ≥600pg/ml in case of clinical signs of heart failure * acute coronary syndrome ≤ 3 months * severe arterial hypertension (concomitant use of more than 4 different antihypertensive drug classes) * acute respiratory distress syndrome with need for mechanical ventilation * patients who at not capable of home blood pressure monitoring * patients who cannot be switched to an alternative medication

- women capable of bearing children as well as pregnant and breastfeeding women - participant in another interventional trail - at screening visit, no oral medication intake possible - advanced heart failure nyha stage iii-iv - left ventricular ejection fraction <30% or ntprobnp ≥600pg/ml in case of clinical signs of heart failure - acute coronary syndrome ≤ 3 months - severe arterial hypertension (concomitant use of more than 4 different antihypertensive drug classes) - acute respiratory distress syndrome with need for mechanical ventilation - patients who at not capable of home blood pressure monitoring - patients who cannot be switched to an alternative medication

- women capable of bearing children as well as pregnant and breastfeeding women - participant in another interventional trail - at screening visit, no oral medication intake possible - advanced heart failure nyha stage iii-iv - left ventricular ejection fraction <30% or ntprobnp ≥600pg/ml in case of clinical signs of heart failure - acute coronary syndrome ≤ 3 months - severe arterial hypertension (concomitant use of more than 4 different antihypertensive drug classes) - acute respiratory distress syndrome with need for mechanical ventilation - patients who at not capable of home blood pressure monitoring - patients who cannot be switched to an alternative medication