1. inability to comprehend and to follow all required study procedures. 2. allergy or severe reactions to the study drugs 3. patients with known prolonged qtc syndrome, ventricular cardiac arrhythmias, including torsade de pointes, second or third degree heart block, qtc interval \>480ms 4. patients taking medication that will potentially interact with l interferon beta-1b or hydroxychloroquine 5. patients with known underlying retinopathy 6. patients with g6pd deficiency 7. patients with known history of severe depression 8. received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to recruitment in this study or expect to receive an experimental agent during this study. 9. to participate in an unrelated trial during the current clinical trial. nevertheless, the patients have the right to withdraw from the current clinical trial to join another clinical trial. 10. have a history of alcohol or drug abuse in the last 5 years. 11. have any condition that the investigator believes may interfere with successful completion of the study.

1. inability to comprehend and to follow all required study procedures. 2. allergy or severe reactions to the study drugs 3. patients with known prolonged qtc syndrome, ventricular cardiac arrhythmias, including torsade de pointes, second or third degree heart block, qtc interval \>480ms 4. patients taking medication that will potentially interact with l interferon beta-1b or hydroxychloroquine 5. patients with known underlying retinopathy 6. patients with g6pd deficiency 7. patients with known history of severe depression 8. received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to recruitment in this study or expect to receive an experimental agent during this study. 9. to participate in an unrelated trial during the current clinical trial. nevertheless, the patients have the right to withdraw from the current clinical trial to join another clinical trial. 10. have a history of alcohol or drug abuse in the last 5 years. 11. have any condition that the investigator believes may interfere with successful completion of the study.

inability to comprehend and to follow all required study procedures. allergy or severe reactions to the study drugs patients with known prolonged qtc syndrome, ventricular cardiac arrhythmias, including torsade de pointes, second or third degree heart block, qtc interval >480ms patients taking medication that will potentially interact with l interferon beta-1b or hydroxychloroquine patients with known underlying retinopathy patients with g6pd deficiency patients with known history of severe depression received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to recruitment in this study or expect to receive an experimental agent during this study. to participate in an unrelated trial during the current clinical trial. nevertheless, the patients have the right to withdraw from the current clinical trial to join another clinical trial. have a history of alcohol or drug abuse in the last 5 years. have any condition that the investigator believes may interfere with successful completion of the study.

inability to comprehend and to follow all required study procedures. allergy or severe reactions to the study drugs patients with known prolonged qtc syndrome, ventricular cardiac arrhythmias, including torsade de pointes, second or third degree heart block, qtc interval >480ms patients taking medication that will potentially interact with l interferon beta-1b or hydroxychloroquine patients with known underlying retinopathy patients with g6pd deficiency patients with known history of severe depression received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to recruitment in this study or expect to receive an experimental agent during this study. to participate in an unrelated trial during the current clinical trial. nevertheless, the patients have the right to withdraw from the current clinical trial to join another clinical trial. have a history of alcohol or drug abuse in the last 5 years. have any condition that the investigator believes may interfere with successful completion of the study.

1. inability to comprehend and to follow all required study procedures. 2. allergy or severe reactions to the study drugs 3. patients with known prolonged qtc syndrome, ventricular cardiac arrhythmias, including torsade de pointes, second or third degree heart block, qtc interval >480ms 4. patients taking medication that will potentially interact with l interferon beta-1b or hydroxychloroquine 5. patients with known underlying retinopathy 6. patients with g6pd deficiency 7. patients with known history of severe depression 8. received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to recruitment in this study or expect to receive an experimental agent during this study. 9. to participate in an unrelated trial during the current clinical trial. nevertheless, the patients have the right to withdraw from the current clinical trial to join another clinical trial. 10. have a history of alcohol or drug abuse in the last 5 years. 11. have any condition that the investigator believes may interfere with successful completion of the study.

1. inability to comprehend and to follow all required study procedures. 2. allergy or severe reactions to the study drugs 3. patients with known prolonged qtc syndrome, ventricular cardiac arrhythmias, including torsade de pointes, second or third degree heart block, qtc interval >480ms 4. patients taking medication that will potentially interact with l interferon beta-1b or hydroxychloroquine 5. patients with known underlying retinopathy 6. patients with g6pd deficiency 7. patients with known history of severe depression 8. received an experimental agent (vaccine, drug, biologic, device, blood product, or medication) within 1 month prior to recruitment in this study or expect to receive an experimental agent during this study. 9. to participate in an unrelated trial during the current clinical trial. nevertheless, the patients have the right to withdraw from the current clinical trial to join another clinical trial. 10. have a history of alcohol or drug abuse in the last 5 years. 11. have any condition that the investigator believes may interfere with successful completion of the study.