inclusion criteria: * patients who have given their written informed consent. if it is considered that obtaining written consent could constitute a factor for the transmission of the disease (given the high contagiousness of the sars-cov-2 virus), it will be permitted to obtain duly justified verbal consent in the patient's medical history. * clinical diagnosis or confirmed by analytical tests (pcr of viral rna or detection of antisars-cov-2 antibodies) that requires care in hospital and that are grade 3 or 4 of the who 7-point ordinal scale of severity categorization for covid. * platelets\> 50,000 / ul, neutrophils\> 500 / ul * kidney or liver failure is not a contraindication, dose adjustment will be made according to the smpc * women of childbearing potential who are sexually active, not undergoing a hysterectomy or double adnexectomy, should follow the following indications for contraception: * negative serum or urine pregnancy test in the 72 hours prior to the start of treatment. * use of a medically accepted contraceptive method during: 2 months prior to the start of study treatment, during the study and up to 3 months after the last dose of treatment.

inclusion criteria: * patients who have given their written informed consent. if it is considered that obtaining written consent could constitute a factor for the transmission of the disease (given the high contagiousness of the sars-cov-2 virus), it will be permitted to obtain duly justified verbal consent in the patient's medical history. * clinical diagnosis or confirmed by analytical tests (pcr of viral rna or detection of antisars-cov-2 antibodies) that requires care in hospital and that are grade 3 or 4 of the who 7-point ordinal scale of severity categorization for covid. * platelets\> 50,000 / ul, neutrophils\> 500 / ul * kidney or liver failure is not a contraindication, dose adjustment will be made according to the smpc * women of childbearing potential who are sexually active, not undergoing a hysterectomy or double adnexectomy, should follow the following indications for contraception: * negative serum or urine pregnancy test in the 72 hours prior to the start of treatment. * use of a medically accepted contraceptive method during: 2 months prior to the start of study treatment, during the study and up to 3 months after the last dose of treatment.

inclusion criteria: - patients who have given their written informed consent. if it is considered that obtaining written consent could constitute a factor for the transmission of the disease (given the high contagiousness of the sars-cov-2 virus), it will be permitted to obtain duly justified verbal consent in the patient's medical history. - clinical diagnosis or confirmed by analytical tests (pcr of viral rna or detection of antisars-cov-2 antibodies) that requires care in hospital and that are grade 3 or 4 of the who 7-point ordinal scale of severity categorization for covid. - platelets> 50,000 / ul, neutrophils> 500 / ul - kidney or liver failure is not a contraindication, dose adjustment will be made according to the smpc - women of childbearing potential who are sexually active, not undergoing a hysterectomy or double adnexectomy, should follow the following indications for contraception: - negative serum or urine pregnancy test in the 72 hours prior to the start of treatment. - use of a medically accepted contraceptive method during: 2 months prior to the start of study treatment, during the study and up to 3 months after the last dose of treatment.

inclusion criteria: - patients who have given their written informed consent. if it is considered that obtaining written consent could constitute a factor for the transmission of the disease (given the high contagiousness of the sars-cov-2 virus), it will be permitted to obtain duly justified verbal consent in the patient's medical history. - clinical diagnosis or confirmed by analytical tests (pcr of viral rna or detection of antisars-cov-2 antibodies) that requires care in hospital and that are grade 3 or 4 of the who 7-point ordinal scale of severity categorization for covid. - platelets> 50,000 / ul, neutrophils> 500 / ul - kidney or liver failure is not a contraindication, dose adjustment will be made according to the smpc - women of childbearing potential who are sexually active, not undergoing a hysterectomy or double adnexectomy, should follow the following indications for contraception: - negative serum or urine pregnancy test in the 72 hours prior to the start of treatment. - use of a medically accepted contraceptive method during: 2 months prior to the start of study treatment, during the study and up to 3 months after the last dose of treatment.