inclusion criteria: * age \>18 at the time of screening * subject must be able to understand and provide informed consent * hospitalized with covid-19 (+) disease (confirmed by polymerase chain reaction (pcr) assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid)) * not on mechanical ventilation and/or ecmo * evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation (spo2) at rest in ambient air with spo2 ≤ 94% 2. tachypnea with resting respiration rate \> 25 breaths/minute 3. partial pressure of oxygen (pao2) / fraction of inspired oxygen (fio2) ≤ 300 mmhg 4. chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia 5. c-reactive protein (crp) \>35 mg/l

inclusion criteria: * age \>18 at the time of screening * subject must be able to understand and provide informed consent * hospitalized with covid-19 (+) disease (confirmed by polymerase chain reaction (pcr) assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid)) * not on mechanical ventilation and/or ecmo * evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation (spo2) at rest in ambient air with spo2 ≤ 94% 2. tachypnea with resting respiration rate \> 25 breaths/minute 3. partial pressure of oxygen (pao2) / fraction of inspired oxygen (fio2) ≤ 300 mmhg 4. chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia 5. c-reactive protein (crp) \>35 mg/l

inclusion criteria: age >18 at the time of screening subject must be able to understand and provide informed consent hospitalized with covid-19 (+) disease (confirmed by polymerase chain reaction (pcr) assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid)) not on mechanical ventilation and/or ecmo evidence of pulmonary involvement with at least 2 of the following: oxygen saturation (spo2) at rest in ambient air with spo2 ≤ 94% tachypnea with resting respiration rate > 25 breaths/minute partial pressure of oxygen (pao2) / fraction of inspired oxygen (fio2) ≤ 300 mmhg chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia c-reactive protein (crp) >35 mg/l

inclusion criteria: age >18 at the time of screening subject must be able to understand and provide informed consent hospitalized with covid-19 (+) disease (confirmed by polymerase chain reaction (pcr) assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid)) not on mechanical ventilation and/or ecmo evidence of pulmonary involvement with at least 2 of the following: oxygen saturation (spo2) at rest in ambient air with spo2 ≤ 94% tachypnea with resting respiration rate > 25 breaths/minute partial pressure of oxygen (pao2) / fraction of inspired oxygen (fio2) ≤ 300 mmhg chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia c-reactive protein (crp) >35 mg/l

inclusion criteria: age >18 at the time of screening. subject must be able to understand and provide informed consent. hospitalized with covid19+ disease (confirmed by pcr assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid). not on mechanical ventilation and/or ecmo evidence of pulmonary involvement with at least 2 of the following: oxygen saturation at rest in ambient air with spo2 ≤ 94% tachypnea with resting respiration rate > 25 breaths/minute pao2/fio2 ≤ 300 mmhg chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia crp >35 mg/l

inclusion criteria: age >18 at the time of screening. subject must be able to understand and provide informed consent. hospitalized with covid19+ disease (confirmed by pcr assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid). not on mechanical ventilation and/or ecmo evidence of pulmonary involvement with at least 2 of the following: oxygen saturation at rest in ambient air with spo2 ≤ 94% tachypnea with resting respiration rate > 25 breaths/minute pao2/fio2 ≤ 300 mmhg chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia crp >35 mg/l

inclusion criteria: - age >18 at the time of screening. - subject must be able to understand and provide informed consent. - hospitalized with covid19+ disease (confirmed by pcr assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid). - not on mechanical ventilation and/or ecmo - evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation at rest in ambient air with spo2 ≤ 94% 2. tachypnea with resting respiration rate > 25 breaths/minute 3. pao2/fio2 ≤ 300 mmhg 4. chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia 5. crp >35 mg/l

inclusion criteria: - age >18 at the time of screening. - subject must be able to understand and provide informed consent. - hospitalized with covid19+ disease (confirmed by pcr assay from any specimen (e.g. respiratory, blood, urine, stool, other bodily fluid). - not on mechanical ventilation and/or ecmo - evidence of pulmonary involvement with at least 2 of the following: 1. oxygen saturation at rest in ambient air with spo2 ≤ 94% 2. tachypnea with resting respiration rate > 25 breaths/minute 3. pao2/fio2 ≤ 300 mmhg 4. chest imaging (radiograph, ct scan, or lung ultrasound) with abnormalities consistent covid-19 pneumonia 5. crp >35 mg/l