inclusion criteria: 1. acceptance of participation in the study by the patient or legal representative. 2. patients of any gender, 18 years or older. 3. confirmed diagnosis by pcr+ of sars-cov-2 infection. 4. covid-19 positive patients who grades 4, 5 or 6. * grade 4: hospitalized requiring oxygen therapy. * grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. 5. levels of il-6 ≥ 3 times the upper limit of normality

inclusion criteria: 1. acceptance of participation in the study by the patient or legal representative. 2. patients of any gender, 18 years or older. 3. confirmed diagnosis by pcr+ of sars-cov-2 infection. 4. covid-19 positive patients who grades 4, 5 or 6. * grade 4: hospitalized requiring oxygen therapy. * grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. 5. levels of il-6 ≥ 3 times the upper limit of normality

inclusion criteria: acceptance of participation in the study by the patient or legal representative. patients of any gender, 18 years or older. confirmed diagnosis by pcr+ of sars-cov-2 infection. covid-19 positive patients who grades 4, 5 or 6. grade 4: hospitalized requiring oxygen therapy. grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. levels of il-6 ≥ 3 times the upper limit of normality

inclusion criteria: acceptance of participation in the study by the patient or legal representative. patients of any gender, 18 years or older. confirmed diagnosis by pcr+ of sars-cov-2 infection. covid-19 positive patients who grades 4, 5 or 6. grade 4: hospitalized requiring oxygen therapy. grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. levels of il-6 ≥ 3 times the upper limit of normality

inclusion criteria: acceptance of participation in the study by the patient or legal representative. patients of any gender, 18 years or older. confirmed diagnosis by pcr+ of sars-cov-2 infection. covid-19 positive patients who grades 4, 5 or 6. grade 4: hospitalized requiring oxygen therapy. grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. grade 6: hospitalized requiring ecmo, mechanical ventilation or both.

inclusion criteria: acceptance of participation in the study by the patient or legal representative. patients of any gender, 18 years or older. confirmed diagnosis by pcr+ of sars-cov-2 infection. covid-19 positive patients who grades 4, 5 or 6. grade 4: hospitalized requiring oxygen therapy. grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. grade 6: hospitalized requiring ecmo, mechanical ventilation or both.

inclusion criteria: 1. acceptance of participation in the study by the patient or legal representative. 2. patients of any gender, 18 years or older. 3. confirmed diagnosis by pcr+ of sars-cov-2 infection. 4. covid-19 positive patients who grades 4, 5 or 6. - grade 4: hospitalized requiring oxygen therapy. - grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. - grade 6: hospitalized requiring ecmo, mechanical ventilation or both.exclusion criteria: 5. levels of il-6 ≥ 3 times the upper limit of normality

inclusion criteria: 1. acceptance of participation in the study by the patient or legal representative. 2. patients of any gender, 18 years or older. 3. confirmed diagnosis by pcr+ of sars-cov-2 infection. 4. covid-19 positive patients who grades 4, 5 or 6. - grade 4: hospitalized requiring oxygen therapy. - grade 5: hospitalized requiring high-flow oxygen therapy, noninvasive mechanical ventilation, or both. - grade 6: hospitalized requiring ecmo, mechanical ventilation or both.exclusion criteria: 5. levels of il-6 ≥ 3 times the upper limit of normality