* negative sars-cov-2 rt-pcr on nasopharyngeal swab * known hypersensitivity to hydroxychloroquine, azithromycin or a macrolide family member * long term prescribed treatment contraindicated with azithromycin (colchicine, ergotamine, dihydroergotamine) and/or hydroxychloroquine (citalopram, escitalopram, hydroxyzine, domperidone, piperaquin) * retinopathy or maculopathy * porphyria * severe renal failure (gfr less than 30 ml/min/m²) * dyskaliemia, (ie less than 3,5 mmol/l or more than 5,5 mmol/l) * hypomagnesiemia, ie less than 0,7 mmol/l * severe cholestasis, cirrhosis or severe hepatic failure * known cardiac medical history of congestive heart failure or myocardial infarction * bradycardia less than 50 beats per minute * prolonged corrected qt interval, (ie cqt more than 440 ms in men and 450 ms in women) or medical history of ventricular cardiac rhythm disorders * blood disorders with history of hematopoietic stem cells allograft * known history of g6pd deficiency * pregnancy * breastfeeding * subject protected by law under guardianship of curatorship * inability to take oral medications

* negative sars-cov-2 rt-pcr on nasopharyngeal swab * known hypersensitivity to hydroxychloroquine, azithromycin or a macrolide family member * long term prescribed treatment contraindicated with azithromycin (colchicine, ergotamine, dihydroergotamine) and/or hydroxychloroquine (citalopram, escitalopram, hydroxyzine, domperidone, piperaquin) * retinopathy or maculopathy * porphyria * severe renal failure (gfr less than 30 ml/min/m²) * dyskaliemia, (ie less than 3,5 mmol/l or more than 5,5 mmol/l) * hypomagnesiemia, ie less than 0,7 mmol/l * severe cholestasis, cirrhosis or severe hepatic failure * known cardiac medical history of congestive heart failure or myocardial infarction * bradycardia less than 50 beats per minute * prolonged corrected qt interval, (ie cqt more than 440 ms in men and 450 ms in women) or medical history of ventricular cardiac rhythm disorders * blood disorders with history of hematopoietic stem cells allograft * known history of g6pd deficiency * pregnancy * breastfeeding * subject protected by law under guardianship of curatorship * inability to take oral medications

- negative sars-cov-2 rt-pcr on nasopharyngeal swab - known hypersensitivity to hydroxychloroquine, azithromycin or a macrolide family member - long term prescribed treatment contraindicated with azithromycin (colchicine, ergotamine, dihydroergotamine) and/or hydroxychloroquine (citalopram, escitalopram, hydroxyzine, domperidone, piperaquin) - retinopathy or maculopathy - porphyria - severe renal failure (gfr less than 30 ml/min/m²) - dyskaliemia, (ie less than 3,5 mmol/l or more than 5,5 mmol/l) - hypomagnesiemia, ie less than 0,7 mmol/l - severe cholestasis, cirrhosis or severe hepatic failure - known cardiac medical history of congestive heart failure or myocardial infarction - bradycardia less than 50 beats per minute - prolonged corrected qt interval, (ie cqt more than 440 ms in men and 450 ms in women) or medical history of ventricular cardiac rhythm disorders - blood disorders with history of hematopoietic stem cells allograft - known history of g6pd deficiency - pregnancy - breastfeeding - subject protected by law under guardianship of curatorship - inability to take oral medications

- negative sars-cov-2 rt-pcr on nasopharyngeal swab - known hypersensitivity to hydroxychloroquine, azithromycin or a macrolide family member - long term prescribed treatment contraindicated with azithromycin (colchicine, ergotamine, dihydroergotamine) and/or hydroxychloroquine (citalopram, escitalopram, hydroxyzine, domperidone, piperaquin) - retinopathy or maculopathy - porphyria - severe renal failure (gfr less than 30 ml/min/m²) - dyskaliemia, (ie less than 3,5 mmol/l or more than 5,5 mmol/l) - hypomagnesiemia, ie less than 0,7 mmol/l - severe cholestasis, cirrhosis or severe hepatic failure - known cardiac medical history of congestive heart failure or myocardial infarction - bradycardia less than 50 beats per minute - prolonged corrected qt interval, (ie cqt more than 440 ms in men and 450 ms in women) or medical history of ventricular cardiac rhythm disorders - blood disorders with history of hematopoietic stem cells allograft - known history of g6pd deficiency - pregnancy - breastfeeding - subject protected by law under guardianship of curatorship - inability to take oral medications