inclusion criteria: 1. 18 years or older 2. confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay 3. moderate or severe ards, based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2): 1. moderate ards: pao2/fio2 100-200 mmhg or 2. severe ards: pao2/fio2 ≤100 mmhg 4. if on invasive or noninvasive (bipap) mechanical ventilator, peep ≥5 cm h2o 5. bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules.

inclusion criteria: 1. 18 years or older 2. confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay 3. moderate or severe ards, based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2): 1. moderate ards: pao2/fio2 100-200 mmhg or 2. severe ards: pao2/fio2 ≤100 mmhg 4. if on invasive or noninvasive (bipap) mechanical ventilator, peep ≥5 cm h2o 5. bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules.

inclusion criteria: 18 years or older confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay moderate or severe ards, based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2): moderate ards: pao2/fio2 100-200 mmhg or severe ards: pao2/fio2 ≤100 mmhg if on invasive or noninvasive (bipap) mechanical ventilator, peep ≥5 cm h2o bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules.

inclusion criteria: 18 years or older confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay moderate or severe ards, based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2): moderate ards: pao2/fio2 100-200 mmhg or severe ards: pao2/fio2 ≤100 mmhg if on invasive or noninvasive (bipap) mechanical ventilator, peep ≥5 cm h2o bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules.

inclusion criteria: 1. 18 years or older 2. confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay 3. moderate or severe ards, based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2): 1. moderate ards: pao2/fio2 100-200 mmhg or 2. severe ards: pao2/fio2 ≤100 mmhg 4. if on invasive or noninvasive (bipap) mechanical ventilator, peep ≥5 cm h2o 5. bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules.

inclusion criteria: 1. 18 years or older 2. confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay 3. moderate or severe ards, based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2): 1. moderate ards: pao2/fio2 100-200 mmhg or 2. severe ards: pao2/fio2 ≤100 mmhg 4. if on invasive or noninvasive (bipap) mechanical ventilator, peep ≥5 cm h2o 5. bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules.

inclusion criteria: 1) 18 years or older 2) confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay 3) moderate to severe acute respiratory distress syndrome (ards), based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2). based on the berlin criteria noted below. 1. moderate ards: pao2/fio2 100-200 mmhg, on invasive or noninvasive mechanical ventilation settings that include eep ≥5 cm h2o 2. severe ards: pao2/fio2 ≤100 mmhg on ventilator settings that include peep ≥5 cm h2o and - bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules. - respiratory failure not fully explained by cardiac failure or fluid overload.

inclusion criteria: 1) 18 years or older 2) confirmed sars-cov2 infection real-time reverse transcription polymerase chain reaction (rt-pcr) assay 3) moderate to severe acute respiratory distress syndrome (ards), based on the degree of impairment of oxygenation as defined by the ratio of arterial oxygen tension to fraction of inspired oxygen (pao2/fio2). based on the berlin criteria noted below. 1. moderate ards: pao2/fio2 100-200 mmhg, on invasive or noninvasive mechanical ventilation settings that include eep ≥5 cm h2o 2. severe ards: pao2/fio2 ≤100 mmhg on ventilator settings that include peep ≥5 cm h2o and - bilateral opacities present on chest radiograph or computed tomographic (ct) scan, that are not fully explained by pleural effusions, lung collapse, or lung nodules. - respiratory failure not fully explained by cardiac failure or fluid overload.