1. currently receiving extracorporeal membrane oxygenation (ecmo) 2. severe chronic respiratory disease requiring use of home oxygen 3. pregnant or lactating 4. known hypersensitivity to dimethyl sulfoxide (dmso) 5. unstable hemodynamics as deemed by the treating physician/investigator including but not limited to unstable, ventricular tachycardia or new cardiac arrythmia requiring cardioversion. 6. uncontrolled bacterial or fungal co-infection 7. any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment 8. inability to obtain informed consent (from patient or legally appropriate proxy) 9. presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin. 10. respiratory failure not fully explained by cardiac failure or fluid overload.

1. currently receiving extracorporeal membrane oxygenation (ecmo) 2. severe chronic respiratory disease requiring use of home oxygen 3. pregnant or lactating 4. known hypersensitivity to dimethyl sulfoxide (dmso) 5. unstable hemodynamics as deemed by the treating physician/investigator including but not limited to unstable, ventricular tachycardia or new cardiac arrythmia requiring cardioversion. 6. uncontrolled bacterial or fungal co-infection 7. any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment 8. inability to obtain informed consent (from patient or legally appropriate proxy) 9. presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin. 10. respiratory failure not fully explained by cardiac failure or fluid overload.

1. currently receiving extracorporeal membrane oxygenation (ecmo) 2. severe chronic respiratory disease requiring use of home oxygen 3. pregnant or lactating 4. known hypersensitivity to dimethyl sulfoxide (dmso) 5. unstable hemodynamics (ventricular tachycardia or fibrillation) 6. uncontrolled bacterial or fungal co-infection 7. any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment 8. inability to obtain informed consent (from patient or legally appropriate proxy) 9. presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin.

1. currently receiving extracorporeal membrane oxygenation (ecmo) 2. severe chronic respiratory disease requiring use of home oxygen 3. pregnant or lactating 4. known hypersensitivity to dimethyl sulfoxide (dmso) 5. unstable hemodynamics (ventricular tachycardia or fibrillation) 6. uncontrolled bacterial or fungal co-infection 7. any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment 8. inability to obtain informed consent (from patient or legally appropriate proxy) 9. presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin.

currently receiving extracorporeal membrane oxygenation (ecmo) severe chronic respiratory disease requiring use of home oxygen pregnant or lactating known hypersensitivity to dimethyl sulfoxide (dmso) unstable hemodynamics (ventricular tachycardia or fibrillation) uncontrolled bacterial or fungal co-infection any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment inability to obtain informed consent (from patient or legally appropriate proxy) presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin.

currently receiving extracorporeal membrane oxygenation (ecmo) severe chronic respiratory disease requiring use of home oxygen pregnant or lactating known hypersensitivity to dimethyl sulfoxide (dmso) unstable hemodynamics (ventricular tachycardia or fibrillation) uncontrolled bacterial or fungal co-infection any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment inability to obtain informed consent (from patient or legally appropriate proxy) presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin.

1. currently receiving extracorporeal membrane oxygenation (ecmo) 2. severe chronic respiratory disease requiring use of home oxygen 3. pregnant or lactating 4. known hypersensitivity to dimethyl sulfoxide (dmso) 5. unstable hemodynamics (ventricular tachycardia or fibrillation) 6. uncontrolled bacterial or fungal co-infection 7. any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment 8. inability to obtain informed consent (from patient or legally appropriate proxy) 9. presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin.

1. currently receiving extracorporeal membrane oxygenation (ecmo) 2. severe chronic respiratory disease requiring use of home oxygen 3. pregnant or lactating 4. known hypersensitivity to dimethyl sulfoxide (dmso) 5. unstable hemodynamics (ventricular tachycardia or fibrillation) 6. uncontrolled bacterial or fungal co-infection 7. any end-stage organ disease or condition, which in the opinion of the investigator, makes the patient an unsuitable candidate for treatment 8. inability to obtain informed consent (from patient or legally appropriate proxy) 9. presence of any contraindication to receiving prophylactic low dose unfractionated or low molecular weight heparin.