* patients with contraindications to anticoagulation 1. congenital hemorrhagic disorders 2. hypersensitivity to tinzaparin or uhf or to any of the excipients 3. current or history of immune-mediated heparin-induced thrombocytopenia 4. active major haemorrhage or conditions predisposing to major haemorrhage. major haemorrhage is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g. intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level of 20 g/l (1.24 mmol/l) or more, or c) leads to transfusion of 2 or more units of whole blood or red blood cells. 5. septic endocarditis * patients with need for anticoagulant therapy. for example: atrial fibrillation, venous thromboembolism, mechanical valve, etc.

* patients with contraindications to anticoagulation 1. congenital hemorrhagic disorders 2. hypersensitivity to tinzaparin or uhf or to any of the excipients 3. current or history of immune-mediated heparin-induced thrombocytopenia 4. active major haemorrhage or conditions predisposing to major haemorrhage. major haemorrhage is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g. intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level of 20 g/l (1.24 mmol/l) or more, or c) leads to transfusion of 2 or more units of whole blood or red blood cells. 5. septic endocarditis * patients with need for anticoagulant therapy. for example: atrial fibrillation, venous thromboembolism, mechanical valve, etc.

patients with contraindications to anticoagulation congenital hemorrhagic disorders hypersensitivity to tinzaparin or uhf or to any of the excipients current or history of immune-mediated heparin-induced thrombocytopenia active major haemorrhage or conditions predisposing to major haemorrhage. major haemorrhage is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g. intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level of 20 g/l (1.24 mmol/l) or more, or c) leads to transfusion of 2 or more units of whole blood or red blood cells. septic endocarditis patients with need for anticoagulant therapy. for example: atrial fibrillation, venous thromboembolism, mechanical valve, etc.

patients with contraindications to anticoagulation congenital hemorrhagic disorders hypersensitivity to tinzaparin or uhf or to any of the excipients current or history of immune-mediated heparin-induced thrombocytopenia active major haemorrhage or conditions predisposing to major haemorrhage. major haemorrhage is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g. intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level of 20 g/l (1.24 mmol/l) or more, or c) leads to transfusion of 2 or more units of whole blood or red blood cells. septic endocarditis patients with need for anticoagulant therapy. for example: atrial fibrillation, venous thromboembolism, mechanical valve, etc.

- patients with contraindications to anticoagulation 1. congenital hemorrhagic disorders 2. hypersensitivity to tinzaparin or uhf or to any of the excipients 3. current or history of immune-mediated heparin-induced thrombocytopenia 4. active major haemorrhage or conditions predisposing to major haemorrhage. major haemorrhage is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g. intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level of 20 g/l (1.24 mmol/l) or more, or c) leads to transfusion of 2 or more units of whole blood or red blood cells. 5. septic endocarditis - patients with need for anticoagulant therapy. for example: atrial fibrillation, venous thromboembolism, mechanical valve, etc.

- patients with contraindications to anticoagulation 1. congenital hemorrhagic disorders 2. hypersensitivity to tinzaparin or uhf or to any of the excipients 3. current or history of immune-mediated heparin-induced thrombocytopenia 4. active major haemorrhage or conditions predisposing to major haemorrhage. major haemorrhage is defined as fulfilling any one of these three criteria: a) occurs in a critical area or organ (e.g. intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, intra-uterine or intramuscular with compartment syndrome), b) causes a fall in haemoglobin level of 20 g/l (1.24 mmol/l) or more, or c) leads to transfusion of 2 or more units of whole blood or red blood cells. 5. septic endocarditis - patients with need for anticoagulant therapy. for example: atrial fibrillation, venous thromboembolism, mechanical valve, etc.