there are 2 groups of research subjects: plasma donor and recipients volunteer plasma donors can donate convalescent plasma if they: * have adequate antibody levels against covid-19 per fda guidelines * have had no symptoms of covid-19 for at least 14 days * meet routine plasma donation criteria inclusion criteria for plasma recipients: * adults 18 years of age or older * hospitalized with pcr+ covid-19 infection * if female must not be pregnant and/or breastfeeding. exclusion criteria for plasma recipients: * unable to randomize patient within 14 days of admission to stony brook hospital (or any other hospital if a transfer to stony brook hospital). * in the treating physician's opinion, the patient cannot tolerate a 450-550 ml infusion of plasma over up to 8 hours (4 hours max per unit), even if prophylaxed with intravenous diuretic * contraindication to transfusion or history of prior reactions to blood transfusions

there are 2 groups of research subjects: plasma donor and recipients volunteer plasma donors can donate convalescent plasma if they: * have adequate antibody levels against covid-19 per fda guidelines * have had no symptoms of covid-19 for at least 14 days * meet routine plasma donation criteria inclusion criteria for plasma recipients: * adults 18 years of age or older * hospitalized with pcr+ covid-19 infection * if female must not be pregnant and/or breastfeeding. exclusion criteria for plasma recipients: * unable to randomize patient within 14 days of admission to stony brook hospital (or any other hospital if a transfer to stony brook hospital). * in the treating physician's opinion, the patient cannot tolerate a 450-550 ml infusion of plasma over up to 8 hours (4 hours max per unit), even if prophylaxed with intravenous diuretic * contraindication to transfusion or history of prior reactions to blood transfusions

there are 2 groups of research subjects: plasma donor and recipients volunteer plasma donors can donate convalescent plasma if they: - have adequate antibody levels against covid-19 per fda guidelines - have had no symptoms of covid-19 for at least 14 days - meet routine plasma donation criteria inclusion criteria for plasma recipients: - adults 18 years of age or older - hospitalized with pcr+ covid-19 infection - if female must not be pregnant and/or breastfeeding. exclusion criteria for plasma recipients: - unable to randomize patient within 14 days of admission to stony brook hospital (or any other hospital if a transfer to stony brook hospital). - in the treating physician's opinion, the patient cannot tolerate a 450-550 ml infusion of plasma over up to 8 hours (4 hours max per unit), even if prophylaxed with intravenous diuretic - contraindication to transfusion or history of prior reactions to blood transfusions

there are 2 groups of research subjects: plasma donor and recipients volunteer plasma donors can donate convalescent plasma if they: - have adequate antibody levels against covid-19 per fda guidelines - have had no symptoms of covid-19 for at least 14 days - meet routine plasma donation criteria inclusion criteria for plasma recipients: - adults 18 years of age or older - hospitalized with pcr+ covid-19 infection - if female must not be pregnant and/or breastfeeding. exclusion criteria for plasma recipients: - unable to randomize patient within 14 days of admission to stony brook hospital (or any other hospital if a transfer to stony brook hospital). - in the treating physician's opinion, the patient cannot tolerate a 450-550 ml infusion of plasma over up to 8 hours (4 hours max per unit), even if prophylaxed with intravenous diuretic - contraindication to transfusion or history of prior reactions to blood transfusions