* covid-19 infection with first symptoms lasting for more than 9 days according to the patient's interview; d1 of symptoms is defined by the first day with fever, cough, shortness of breath, and / or chills related to covid-19 infection; * patients with primary or secondary immune deficiency, including: hiv, chronic hematological disease, solid organ transplant, ongoing immunosuppressive therapy, * long-term corticosteroid therapy defined by a prescription of more than 10 mg/d (prednisone equivalent), * suspected or confirmed infection with bacteria, fungal agents or viruses (in addition to covid-19), * known contraindication to systemic corticosteroids, * systolic blood pressure \<80 mmhg, * spo2 \<90% under 5 l / min of oxygen using medium concentration mask, or higher oxygen requirements, * patient on long-term oxygen therapy, * ongoing mechanical ventilation, * ongoing septic shock ongoing, * ongoing multi-organ failure ongoing, * participating in other covid-19 therapeutic clinical trial * pregnant or breast-feeding woman (oral diagnosis), * no affiliation or beneficiary of health insurance,

* covid-19 infection with first symptoms lasting for more than 9 days according to the patient's interview; d1 of symptoms is defined by the first day with fever, cough, shortness of breath, and / or chills related to covid-19 infection; * patients with primary or secondary immune deficiency, including: hiv, chronic hematological disease, solid organ transplant, ongoing immunosuppressive therapy, * long-term corticosteroid therapy defined by a prescription of more than 10 mg/d (prednisone equivalent), * suspected or confirmed infection with bacteria, fungal agents or viruses (in addition to covid-19), * known contraindication to systemic corticosteroids, * systolic blood pressure \<80 mmhg, * spo2 \<90% under 5 l / min of oxygen using medium concentration mask, or higher oxygen requirements, * patient on long-term oxygen therapy, * ongoing mechanical ventilation, * ongoing septic shock ongoing, * ongoing multi-organ failure ongoing, * participating in other covid-19 therapeutic clinical trial * pregnant or breast-feeding woman (oral diagnosis), * no affiliation or beneficiary of health insurance,

- covid-19 infection with first symptoms lasting for more than 9 days according to the patient's interview; d1 of symptoms is defined by the first day with fever, cough, shortness of breath, and / or chills related to covid-19 infection; - patients with primary or secondary immune deficiency, including: hiv, chronic hematological disease, solid organ transplant, ongoing immunosuppressive therapy, - long-term corticosteroid therapy defined by a prescription of more than 10 mg/d (prednisone equivalent), - suspected or confirmed infection with bacteria, fungal agents or viruses (in addition to covid-19), - known contraindication to systemic corticosteroids, - systolic blood pressure <80 mmhg, - spo2 <90% under 5 l / min of oxygen using medium concentration mask, or higher oxygen requirements, - patient on long-term oxygen therapy, - ongoing mechanical ventilation, - ongoing septic shock ongoing, - ongoing multi-organ failure ongoing, - participating in other covid-19 therapeutic clinical trial - pregnant or breast-feeding woman (oral diagnosis), - no affiliation or beneficiary of health insurance,

- covid-19 infection with first symptoms lasting for more than 9 days according to the patient's interview; d1 of symptoms is defined by the first day with fever, cough, shortness of breath, and / or chills related to covid-19 infection; - patients with primary or secondary immune deficiency, including: hiv, chronic hematological disease, solid organ transplant, ongoing immunosuppressive therapy, - long-term corticosteroid therapy defined by a prescription of more than 10 mg/d (prednisone equivalent), - suspected or confirmed infection with bacteria, fungal agents or viruses (in addition to covid-19), - known contraindication to systemic corticosteroids, - systolic blood pressure <80 mmhg, - spo2 <90% under 5 l / min of oxygen using medium concentration mask, or higher oxygen requirements, - patient on long-term oxygen therapy, - ongoing mechanical ventilation, - ongoing septic shock ongoing, - ongoing multi-organ failure ongoing, - participating in other covid-19 therapeutic clinical trial - pregnant or breast-feeding woman (oral diagnosis), - no affiliation or beneficiary of health insurance,