inclusion criteria: 1. adult patients (≥18 years old) 2. signed informed consent by the patient or designated legal representative 3. confirmatory laboratory test for sars-cov-2 / covid-19 infection 4. pneumonia confirmed by imaging studies 5. agree to venous blood collection according to the protocol 6. need for hospitalization with increased mortality criteria according to published observations, including one or more of the following severity criteria according to the treating medical team: * a. dyspnoea * b. lung infiltrates\> 50% of lung fields by ct * c. a ratio of partial pressure arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) \<300 mmhg * d. pulse oximetry \<90% to ambient air, or a 3% drop in baseline oximetry, or need to increase supplemental oxygen due to chronic hypoxia, as well as the need for supplemental oxygen according to medical judgment and, alteration of one or more of the following laboratory studies at the time of hospital admission: * i. d-dimer \>1 ug/ml * ii. ferritin level \>300 ng/ml * iii. c-reactive protein (crp) \>3mg/l * iv. lactate dehydrogenase (ldh) \>245 u/l * v. lymphopenia \<800 cells/ul * vi. creatine kinase (ck) level \>800 iu/l

inclusion criteria: 1. adult patients (≥18 years old) 2. signed informed consent by the patient or designated legal representative 3. confirmatory laboratory test for sars-cov-2 / covid-19 infection 4. pneumonia confirmed by imaging studies 5. agree to venous blood collection according to the protocol 6. need for hospitalization with increased mortality criteria according to published observations, including one or more of the following severity criteria according to the treating medical team: * a. dyspnoea * b. lung infiltrates\> 50% of lung fields by ct * c. a ratio of partial pressure arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) \<300 mmhg * d. pulse oximetry \<90% to ambient air, or a 3% drop in baseline oximetry, or need to increase supplemental oxygen due to chronic hypoxia, as well as the need for supplemental oxygen according to medical judgment and, alteration of one or more of the following laboratory studies at the time of hospital admission: * i. d-dimer \>1 ug/ml * ii. ferritin level \>300 ng/ml * iii. c-reactive protein (crp) \>3mg/l * iv. lactate dehydrogenase (ldh) \>245 u/l * v. lymphopenia \<800 cells/ul * vi. creatine kinase (ck) level \>800 iu/l

inclusion criteria: adult patients (≥18 years old) signed informed consent by the patient or designated legal representative confirmatory laboratory test for sars-cov-2 / covid-19 infection pneumonia confirmed by imaging studies agree to venous blood collection according to the protocol need for hospitalization with increased mortality criteria according to published observations, including one or more of the following severity criteria according to the treating medical team: a. dyspnoea b. lung infiltrates> 50% of lung fields by ct c. a ratio of partial pressure arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) <300 mmhg d. pulse oximetry <90% to ambient air, or a 3% drop in baseline oximetry, or need to increase supplemental oxygen due to chronic hypoxia, as well as the need for supplemental oxygen according to medical judgment and, alteration of one or more of the following laboratory studies at the time of hospital admission: i. d-dimer >1 ug/ml ii. ferritin level >300 ng/ml iii. c-reactive protein (crp) >3mg/l iv. lactate dehydrogenase (ldh) >245 u/l v. lymphopenia <800 cells/ul vi. creatine kinase (ck) level >800 iu/l

inclusion criteria: adult patients (≥18 years old) signed informed consent by the patient or designated legal representative confirmatory laboratory test for sars-cov-2 / covid-19 infection pneumonia confirmed by imaging studies agree to venous blood collection according to the protocol need for hospitalization with increased mortality criteria according to published observations, including one or more of the following severity criteria according to the treating medical team: a. dyspnoea b. lung infiltrates> 50% of lung fields by ct c. a ratio of partial pressure arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) <300 mmhg d. pulse oximetry <90% to ambient air, or a 3% drop in baseline oximetry, or need to increase supplemental oxygen due to chronic hypoxia, as well as the need for supplemental oxygen according to medical judgment and, alteration of one or more of the following laboratory studies at the time of hospital admission: i. d-dimer >1 ug/ml ii. ferritin level >300 ng/ml iii. c-reactive protein (crp) >3mg/l iv. lactate dehydrogenase (ldh) >245 u/l v. lymphopenia <800 cells/ul vi. creatine kinase (ck) level >800 iu/l

inclusion criteria: 1. adult patients (≥18 years old) 2. signed informed consent by the patient or designated legal representative 3. confirmatory laboratory test for sars-cov-2 / covid-19 infection 4. pneumonia confirmed by imaging studies 5. agree to venous blood collection according to the protocol 6. need for hospitalization with increased mortality criteria according to published observations, including one or more of the following severity criteria according to the treating medical team: - a. dyspnoea - b. lung infiltrates> 50% of lung fields by ct - c. a ratio of partial pressure arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) <300 mmhg - d. pulse oximetry <90% to ambient air, or a 3% drop in baseline oximetry, or need to increase supplemental oxygen due to chronic hypoxia, as well as the need for supplemental oxygen according to medical judgment and, alteration of one or more of the following laboratory studies at the time of hospital admission: - i. d-dimer >1 ug/ml - ii. ferritin level >300 ng/ml - iii. c-reactive protein (crp) >3mg/l - iv. lactate dehydrogenase (ldh) >245 u/l - v. lymphopenia <800 cells/ul - vi. creatine kinase (ck) level >800 iu/l

inclusion criteria: 1. adult patients (≥18 years old) 2. signed informed consent by the patient or designated legal representative 3. confirmatory laboratory test for sars-cov-2 / covid-19 infection 4. pneumonia confirmed by imaging studies 5. agree to venous blood collection according to the protocol 6. need for hospitalization with increased mortality criteria according to published observations, including one or more of the following severity criteria according to the treating medical team: - a. dyspnoea - b. lung infiltrates> 50% of lung fields by ct - c. a ratio of partial pressure arterial oxygen (pao2) to the fraction of inspired oxygen (fio2) <300 mmhg - d. pulse oximetry <90% to ambient air, or a 3% drop in baseline oximetry, or need to increase supplemental oxygen due to chronic hypoxia, as well as the need for supplemental oxygen according to medical judgment and, alteration of one or more of the following laboratory studies at the time of hospital admission: - i. d-dimer >1 ug/ml - ii. ferritin level >300 ng/ml - iii. c-reactive protein (crp) >3mg/l - iv. lactate dehydrogenase (ldh) >245 u/l - v. lymphopenia <800 cells/ul - vi. creatine kinase (ck) level >800 iu/l