1. pyridostigmine allergy 2. if female, pregnancy or breastfeeding 3. meet the following critical illness criteria before signing informed consent and taking the first dose of study medication: 1. . need for mechanical ventilation 2. . admission to the icu for any reason 3. . meet criteria for sepsis or septic shock 4. concomitant autoimmune diseases 5. known immunodeficiency (including hiv infection) 6. need for mechanical ventilation before signing informed consent and taking the first dose of study medication 7. inability to administer orally / enterally 8. use of immunosuppressants or immuno-modulators in the preceding 28 days, including chemotherapeutics and steroids, unless recommended by the treatment medical team as part of the therapeutic approach for sars-cov-2 infection 9. participation in interventional clinical trials in the preceding 28 days (however, participation in observational trials or those with no therapeutic intervention, is allowed)

1. pyridostigmine allergy 2. if female, pregnancy or breastfeeding 3. meet the following critical illness criteria before signing informed consent and taking the first dose of study medication: 1. . need for mechanical ventilation 2. . admission to the icu for any reason 3. . meet criteria for sepsis or septic shock 4. concomitant autoimmune diseases 5. known immunodeficiency (including hiv infection) 6. need for mechanical ventilation before signing informed consent and taking the first dose of study medication 7. inability to administer orally / enterally 8. use of immunosuppressants or immuno-modulators in the preceding 28 days, including chemotherapeutics and steroids, unless recommended by the treatment medical team as part of the therapeutic approach for sars-cov-2 infection 9. participation in interventional clinical trials in the preceding 28 days (however, participation in observational trials or those with no therapeutic intervention, is allowed)

pyridostigmine allergy if female, pregnancy or breastfeeding meet the following critical illness criteria before signing informed consent and taking the first dose of study medication: . need for mechanical ventilation . admission to the icu for any reason . meet criteria for sepsis or septic shock concomitant autoimmune diseases known immunodeficiency (including hiv infection) need for mechanical ventilation before signing informed consent and taking the first dose of study medication inability to administer orally / enterally use of immunosuppressants or immuno-modulators in the preceding 28 days, including chemotherapeutics and steroids, unless recommended by the treatment medical team as part of the therapeutic approach for sars-cov-2 infection participation in interventional clinical trials in the preceding 28 days (however, participation in observational trials or those with no therapeutic intervention, is allowed)

pyridostigmine allergy if female, pregnancy or breastfeeding meet the following critical illness criteria before signing informed consent and taking the first dose of study medication: . need for mechanical ventilation . admission to the icu for any reason . meet criteria for sepsis or septic shock concomitant autoimmune diseases known immunodeficiency (including hiv infection) need for mechanical ventilation before signing informed consent and taking the first dose of study medication inability to administer orally / enterally use of immunosuppressants or immuno-modulators in the preceding 28 days, including chemotherapeutics and steroids, unless recommended by the treatment medical team as part of the therapeutic approach for sars-cov-2 infection participation in interventional clinical trials in the preceding 28 days (however, participation in observational trials or those with no therapeutic intervention, is allowed)

1. pyridostigmine allergy 2. if female, pregnancy or breastfeeding 3. meet the following critical illness criteria before signing informed consent and taking the first dose of study medication: 1. . need for mechanical ventilation 2. . admission to the icu for any reason 3. . meet criteria for sepsis or septic shock 4. concomitant autoimmune diseases 5. known immunodeficiency (including hiv infection) 6. need for mechanical ventilation before signing informed consent and taking the first dose of study medication 7. inability to administer orally / enterally 8. use of immunosuppressants or immuno-modulators in the preceding 28 days, including chemotherapeutics and steroids, unless recommended by the treatment medical team as part of the therapeutic approach for sars-cov-2 infection 9. participation in interventional clinical trials in the preceding 28 days (however, participation in observational trials or those with no therapeutic intervention, is allowed)

1. pyridostigmine allergy 2. if female, pregnancy or breastfeeding 3. meet the following critical illness criteria before signing informed consent and taking the first dose of study medication: 1. . need for mechanical ventilation 2. . admission to the icu for any reason 3. . meet criteria for sepsis or septic shock 4. concomitant autoimmune diseases 5. known immunodeficiency (including hiv infection) 6. need for mechanical ventilation before signing informed consent and taking the first dose of study medication 7. inability to administer orally / enterally 8. use of immunosuppressants or immuno-modulators in the preceding 28 days, including chemotherapeutics and steroids, unless recommended by the treatment medical team as part of the therapeutic approach for sars-cov-2 infection 9. participation in interventional clinical trials in the preceding 28 days (however, participation in observational trials or those with no therapeutic intervention, is allowed)