* refusal to participate expressed by patient or legally authorized representative if they are present * patients with prolonged qt or pr intervals, second or third degree heart block, arrhythmias including torsade de pointes * patients using drugs with potential interaction with hydroxychloroquine + lopinavir/ritonavir, interferon-β 1a، interferon-β 1b. * pregnant or lactating women. * history of alcohol or drug addiction in the past 5 years. * blood alt/ast levels \> 5 times the upper limit of normal on laboratory results.

* refusal to participate expressed by patient or legally authorized representative if they are present * patients with prolonged qt or pr intervals, second or third degree heart block, arrhythmias including torsade de pointes * patients using drugs with potential interaction with hydroxychloroquine + lopinavir/ritonavir, interferon-β 1a، interferon-β 1b. * pregnant or lactating women. * history of alcohol or drug addiction in the past 5 years. * blood alt/ast levels \> 5 times the upper limit of normal on laboratory results.

- refusal to participate expressed by patient or legally authorized representative if they are present - patients with prolonged qt or pr intervals, second or third degree heart block, arrhythmias including torsade de pointes - patients using drugs with potential interaction with hydroxychloroquine + lopinavir/ritonavir, interferon-β 1a، interferon-β 1b. - pregnant or lactating women. - history of alcohol or drug addiction in the past 5 years. - blood alt/ast levels > 5 times the upper limit of normal on laboratory results.

- refusal to participate expressed by patient or legally authorized representative if they are present - patients with prolonged qt or pr intervals, second or third degree heart block, arrhythmias including torsade de pointes - patients using drugs with potential interaction with hydroxychloroquine + lopinavir/ritonavir, interferon-β 1a، interferon-β 1b. - pregnant or lactating women. - history of alcohol or drug addiction in the past 5 years. - blood alt/ast levels > 5 times the upper limit of normal on laboratory results.