inclusion criteria: adult 18 -80 years old must have laboratory confirmed covid-19(a patient with laboratory confirmation (positive rt-pcr) of covid-19 infection, irrespective of clinical signs and symptoms according to ain shams university hospitals consensus statement on management of adult covid-19 patients. must have severe or immediately life-threatening covid-19, * severe disease is defined as: * dyspnea, * respiratory frequency ≥ 30/min, * blood oxygen saturation ≤ 93%, * partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300, and/or lung infiltrates \> 50% within 24 to 48 hours * life-threatening disease is defined as: * respiratory failure, * septic shock, and/or * multiple organ dysfunction or failure * must provide informed consent by patient or his/her legal guardian or professional legal representative

inclusion criteria: adult 18 -80 years old must have laboratory confirmed covid-19(a patient with laboratory confirmation (positive rt-pcr) of covid-19 infection, irrespective of clinical signs and symptoms according to ain shams university hospitals consensus statement on management of adult covid-19 patients. must have severe or immediately life-threatening covid-19, * severe disease is defined as: * dyspnea, * respiratory frequency ≥ 30/min, * blood oxygen saturation ≤ 93%, * partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300, and/or lung infiltrates \> 50% within 24 to 48 hours * life-threatening disease is defined as: * respiratory failure, * septic shock, and/or * multiple organ dysfunction or failure * must provide informed consent by patient or his/her legal guardian or professional legal representative

inclusion criteria: adult 18 -80 years old must have laboratory confirmed covid-19(a patient with laboratory confirmation (positive rt-pcr) of covid-19 infection, irrespective of clinical signs and symptoms according to ain shams university hospitals consensus statement on management of adult covid-19 patients. must have severe or immediately life-threatening covid-19, - severe disease is defined as: - dyspnea, - respiratory frequency ≥ 30/min, - blood oxygen saturation ≤ 93%, - partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or lung infiltrates > 50% within 24 to 48 hours - life-threatening disease is defined as: - respiratory failure, - septic shock, and/or - multiple organ dysfunction or failure - must provide informed consent by patient or his/her legal guardian or professional legal representative

inclusion criteria: adult 18 -80 years old must have laboratory confirmed covid-19(a patient with laboratory confirmation (positive rt-pcr) of covid-19 infection, irrespective of clinical signs and symptoms according to ain shams university hospitals consensus statement on management of adult covid-19 patients. must have severe or immediately life-threatening covid-19, - severe disease is defined as: - dyspnea, - respiratory frequency ≥ 30/min, - blood oxygen saturation ≤ 93%, - partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or lung infiltrates > 50% within 24 to 48 hours - life-threatening disease is defined as: - respiratory failure, - septic shock, and/or - multiple organ dysfunction or failure - must provide informed consent by patient or his/her legal guardian or professional legal representative