* • patient currently in shock or exhibiting hemodynamic instability; * patient with inflammatory bowel disease (crohn's disease or ulcerative colitis), chronic diarrhea or malabsorption; * pregnant or breastfeeding patient * patient with a history of allergic reaction or significant sensitivity to nigella; * the patient is considered by the investigator, for whatever reason, to be an unsuitable candidate for the study.

* • patient currently in shock or exhibiting hemodynamic instability; * patient with inflammatory bowel disease (crohn's disease or ulcerative colitis), chronic diarrhea or malabsorption; * pregnant or breastfeeding patient * patient with a history of allergic reaction or significant sensitivity to nigella; * the patient is considered by the investigator, for whatever reason, to be an unsuitable candidate for the study.

- • patient currently in shock or exhibiting hemodynamic instability; - patient with inflammatory bowel disease (crohn's disease or ulcerative colitis), chronic diarrhea or malabsorption; - pregnant or breastfeeding patient - patient with a history of allergic reaction or significant sensitivity to nigella; - the patient is considered by the investigator, for whatever reason, to be an unsuitable candidate for the study.

- • patient currently in shock or exhibiting hemodynamic instability; - patient with inflammatory bowel disease (crohn's disease or ulcerative colitis), chronic diarrhea or malabsorption; - pregnant or breastfeeding patient - patient with a history of allergic reaction or significant sensitivity to nigella; - the patient is considered by the investigator, for whatever reason, to be an unsuitable candidate for the study.