inclusion criteria: * healthy residents ≥ 18 years at the time of consent, be voluntary and capable of signing the informed consent forms. * be able to understand and comply with study requirements/ procedures. * participants with negative results of sars-cov-2 realtime-pcr (rt-pcr) detection. * for females or sex-partners of males at childbearing age: be willing to use birth control for 3 months after the 2nd dose. * for females of childbearing potential (pausimenia ≤ 2 years ) must: have a negative urine or blood pregnancy test at screening * axillary temperature \< 37.3℃/99.1℉ when screening (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ).

inclusion criteria: * healthy residents ≥ 18 years at the time of consent, be voluntary and capable of signing the informed consent forms. * be able to understand and comply with study requirements/ procedures. * participants with negative results of sars-cov-2 realtime-pcr (rt-pcr) detection. * for females or sex-partners of males at childbearing age: be willing to use birth control for 3 months after the 2nd dose. * for females of childbearing potential (pausimenia ≤ 2 years ) must: have a negative urine or blood pregnancy test at screening * axillary temperature \< 37.3℃/99.1℉ when screening (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ).

inclusion criteria: - healthy residents ≥ 18 years at the time of consent, be voluntary and capable of signing the informed consent forms. - be able to understand and comply with study requirements/ procedures. - participants with negative results of sars-cov-2 realtime-pcr (rt-pcr) detection. - for females or sex-partners of males at childbearing age: be willing to use birth control for 3 months after the 2nd dose. - for females of childbearing potential (pausimenia ≤ 2 years ) must: have a negative urine or blood pregnancy test at screening - axillary temperature < 37.3℃/99.1℉ when screening (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ).

inclusion criteria: - healthy residents ≥ 18 years at the time of consent, be voluntary and capable of signing the informed consent forms. - be able to understand and comply with study requirements/ procedures. - participants with negative results of sars-cov-2 realtime-pcr (rt-pcr) detection. - for females or sex-partners of males at childbearing age: be willing to use birth control for 3 months after the 2nd dose. - for females of childbearing potential (pausimenia ≤ 2 years ) must: have a negative urine or blood pregnancy test at screening - axillary temperature < 37.3℃/99.1℉ when screening (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ).