* previous treatments for curing or preventing covid-19 (including vaccination of various covid-19 vaccines). * history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) or other coronavirus infections. * history of allergy to any components of the candidate vaccine or severe allergic reactions to vaccine or medicine (including, but not limited to, allergic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, or local allergic necrosis (arthus reaction)). * positive for hiv detection. * history or family history of convulsion, epilepsy, encephalopathy, and psychosis. * active stage of malignancies, malignancies without adequate treatments, malignancies with potential risk for recurrence during the study. * severe or uncontrolled cardiovascular, neurological, blood and lymphatic, kidney, liver, respiratory, metabolic and skeletal diseases. * congenital or functional absence of spleen, complete or partial removal of spleen in any case. * chronic administration (defined as ≥ 14 days) of immunosuppressants or other immune-modifying drugs within 6 months prior to the 1st vaccination (eg. corticosteroids, ≥ 0.5 mg/kg/day prednisone or equivalent; but, inhaled and topical steroids are allowed). * planned administration/administration of a vaccine not foreseen by the study protocol less than 7 days before 1st dose of candidate vaccine for inactivated vaccines or 14 days before 1st dose of candidate vaccine for attenuated live vaccines. * receipt of blood products and/or immunoglobulins within 3 months prior to enrollment or expected receipt during the study. * donate or loss ≥ 450 ml of blood within 1 month prior to enrollment, or expected blood donation during the study. * fever: axillary temperature ≥ 37.3℃/99.1℉ within the past 24 hours (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ). * those who participated in other clinical trials 1 month prior to the enrollment or used any investigational or non-registered drug during the study period; those who are unable to finish follow-up or fail in efficacy assessments. * breastfeeding females should not be included. * ineligible for the study based on the assessment of investigator.

* previous treatments for curing or preventing covid-19 (including vaccination of various covid-19 vaccines). * history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) or other coronavirus infections. * history of allergy to any components of the candidate vaccine or severe allergic reactions to vaccine or medicine (including, but not limited to, allergic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, or local allergic necrosis (arthus reaction)). * positive for hiv detection. * history or family history of convulsion, epilepsy, encephalopathy, and psychosis. * active stage of malignancies, malignancies without adequate treatments, malignancies with potential risk for recurrence during the study. * severe or uncontrolled cardiovascular, neurological, blood and lymphatic, kidney, liver, respiratory, metabolic and skeletal diseases. * congenital or functional absence of spleen, complete or partial removal of spleen in any case. * chronic administration (defined as ≥ 14 days) of immunosuppressants or other immune-modifying drugs within 6 months prior to the 1st vaccination (eg. corticosteroids, ≥ 0.5 mg/kg/day prednisone or equivalent; but, inhaled and topical steroids are allowed). * planned administration/administration of a vaccine not foreseen by the study protocol less than 7 days before 1st dose of candidate vaccine for inactivated vaccines or 14 days before 1st dose of candidate vaccine for attenuated live vaccines. * receipt of blood products and/or immunoglobulins within 3 months prior to enrollment or expected receipt during the study. * donate or loss ≥ 450 ml of blood within 1 month prior to enrollment, or expected blood donation during the study. * fever: axillary temperature ≥ 37.3℃/99.1℉ within the past 24 hours (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ). * those who participated in other clinical trials 1 month prior to the enrollment or used any investigational or non-registered drug during the study period; those who are unable to finish follow-up or fail in efficacy assessments. * breastfeeding females should not be included. * ineligible for the study based on the assessment of investigator.

- previous treatments for curing or preventing covid-19 (including vaccination of various covid-19 vaccines). - history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) or other coronavirus infections. - history of allergy to any components of the candidate vaccine or severe allergic reactions to vaccine or medicine (including, but not limited to, allergic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, or local allergic necrosis (arthus reaction)). - positive for hiv detection. - history or family history of convulsion, epilepsy, encephalopathy, and psychosis. - active stage of malignancies, malignancies without adequate treatments, malignancies with potential risk for recurrence during the study. - severe or uncontrolled cardiovascular, neurological, blood and lymphatic, kidney, liver, respiratory, metabolic and skeletal diseases. - congenital or functional absence of spleen, complete or partial removal of spleen in any case. - chronic administration (defined as ≥ 14 days) of immunosuppressants or other immune-modifying drugs within 6 months prior to the 1st vaccination (eg. corticosteroids, ≥ 0.5 mg/kg/day prednisone or equivalent; but, inhaled and topical steroids are allowed). - planned administration/administration of a vaccine not foreseen by the study protocol less than 7 days before 1st dose of candidate vaccine for inactivated vaccines or 14 days before 1st dose of candidate vaccine for attenuated live vaccines. - receipt of blood products and/or immunoglobulins within 3 months prior to enrollment or expected receipt during the study. - donate or loss ≥ 450 ml of blood within 1 month prior to enrollment, or expected blood donation during the study. - fever: axillary temperature ≥ 37.3℃/99.1℉ within the past 24 hours (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ). - those who participated in other clinical trials 1 month prior to the enrollment or used any investigational or non-registered drug during the study period; those who are unable to finish follow-up or fail in efficacy assessments. - breastfeeding females should not be included. - ineligible for the study based on the assessment of investigator.

- previous treatments for curing or preventing covid-19 (including vaccination of various covid-19 vaccines). - history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) or other coronavirus infections. - history of allergy to any components of the candidate vaccine or severe allergic reactions to vaccine or medicine (including, but not limited to, allergic shock, allergic laryngeal edema, allergic purpura, thrombocytopenic purpura, or local allergic necrosis (arthus reaction)). - positive for hiv detection. - history or family history of convulsion, epilepsy, encephalopathy, and psychosis. - active stage of malignancies, malignancies without adequate treatments, malignancies with potential risk for recurrence during the study. - severe or uncontrolled cardiovascular, neurological, blood and lymphatic, kidney, liver, respiratory, metabolic and skeletal diseases. - congenital or functional absence of spleen, complete or partial removal of spleen in any case. - chronic administration (defined as ≥ 14 days) of immunosuppressants or other immune-modifying drugs within 6 months prior to the 1st vaccination (eg. corticosteroids, ≥ 0.5 mg/kg/day prednisone or equivalent; but, inhaled and topical steroids are allowed). - planned administration/administration of a vaccine not foreseen by the study protocol less than 7 days before 1st dose of candidate vaccine for inactivated vaccines or 14 days before 1st dose of candidate vaccine for attenuated live vaccines. - receipt of blood products and/or immunoglobulins within 3 months prior to enrollment or expected receipt during the study. - donate or loss ≥ 450 ml of blood within 1 month prior to enrollment, or expected blood donation during the study. - fever: axillary temperature ≥ 37.3℃/99.1℉ within the past 24 hours (subsequent measurements of temperature should be performed at the same site per participant; temperature measured by other methods should be converted to axillary temperature ). - those who participated in other clinical trials 1 month prior to the enrollment or used any investigational or non-registered drug during the study period; those who are unable to finish follow-up or fail in efficacy assessments. - breastfeeding females should not be included. - ineligible for the study based on the assessment of investigator.