exclusion criteria for first dose vaccination subjects who meet any of the following exclusion criteria shall not be enrolled: 1. individuals with a history of sars-cov-2 infection or use of any preventive products for covid-19 (e.g., a history of any sars-cov-2 vaccines that have or have not been marketed); 2. individuals with sars-cov-2 etiological testing (rt-pcr assay) (individuals with serological testing showing positive igg and/or igm antibodies may be enrolled); 3. individuals with a previous history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) and other human coronavirus infections or diseases; 4. individuals who have fever within 72 hours prior to dose 1 in this trial (oral temperature ≥38°c); 5. pregnant (e.g., positive pregnancy test) or lactating females; 6. individuals who have plan of pregnancy or interruption of effective contraceptive methods within 3 months after the second cross-vaccination in this study; 7. personnel of the study site or the sponsor; 8. individuals with prior history of allergic reaction or anaphylaxis to any vaccine or drug, e.g., hypersensitivity, urticaria, serious eczema, dyspnea, laryngeal edema, and angioedema etc.; 9. individuals who have been vaccinated with any vaccine other than the investigational vaccine used in this clinical trial from 28 days prior to dose 1 to 28 days after dose 2; 10. individuals who have participated in or plan to participate in other drug clinical trials form 28 days prior to dose 1 to 12 months after dose 4 (the second dose of cross-vaccination) in this study; 11. individuals who have hereditary hemorrhagic tendency or coagulation dysfunction (e.g., cytokine defects, coagulation disorders or platelet disorder), or a history of significant bleeding, or a history of injury caused by intramuscular injection or venipuncture; 12. individuals who are confirmed for diseases affecting immune system function, including cancer (except skin basal cell carcinoma), congenital or acquired immunodeficiency (e.g., infection with human immunodeficiency virus (hiv)), and uncontrolled autoimmune disease, based on known history or diagnosis; 13. individuals who have asplenia or functional asplenia; 14. individuals with long-term use (continuous use ≥14 days) of immunosuppressants or other immunomodulatory drugs (e.g., corticosteroids: prednisone or similar drugs) within 6 months prior to dose 1. drugs for topical use (e.g., ointment, eye drops, inhalants or nasal spray) are allowed in this study, and the topical medications should not exceed the recommended dose in the labels for use or induce any signs of systemic exposure; 15. individuals who have received immunoglobulin and/or blood products within 3 months prior to dose 1; 16. individuals who are suspected or known to have alcohol dependency problems or drug abuse that may affect safety evaluation or subject's compliance; 17. individuals who plan to permanently relocate from the local area before the completion of the study or leave the local area for long periods during the study visits; 18. other circumstances considered by the investigator as inappropriate to participate in the study. criteria for postponement of the subsequent doses: if the subjects have any of the followings prior to the subsequent doses, vaccination will be postponed. during the same immunization schedule, the second dose of vaccine will be administered at the 28th day after the first vaccination, with a time window of +5 days: 1. fever within 72 hours prior to the subsequent doses (oral temperature ≥38°c, probability of sars-cov-2 infection shall be excluded); 2. in case of acute diseases prior to the subsequent doses, the investigator shall exclude the probability of sars-cov-2 infection and evaluate the likelihood of short-term recovery for the diseases; exclusion criteria for the subsequent doses: if the subject has any of the followings prior to the subsequent doses, the vaccination shall be terminated for the subject while other study procedures could be continued at the discretion of the investigators: 1. female subjects of childbearing potential who have positive pregnancy test results; 2. subjects who have a serious allergic reaction or serious adverse event causally related to vaccination after previous vaccination; 3. other circumstances considered by the investigator as inappropriate to receive the subsequent doses of the vaccine. criteria for withdrawal from the study 1. subjects experience disability, life-threatening adverse events or serious adverse events and have to prematurely withdraw from this study due to treatment or other reasons. 2. subjects are placed at safety risks by their health conditions which prevent them from continuing to participate in this study. 3. female subjects become pregnant during the study (if at least one dose has been administered, the subject is not required to withdraw from this study but should not receive the subsequent doses. moreover, subsequent observation and follow-up visits should be continued); 4. subjects actively request to withdraw from the study; 5. subjects are considered unsuitable for continuing to participate in this study at the discretion of the investigator.

exclusion criteria for first dose vaccination subjects who meet any of the following exclusion criteria shall not be enrolled: 1. individuals with a history of sars-cov-2 infection or use of any preventive products for covid-19 (e.g., a history of any sars-cov-2 vaccines that have or have not been marketed); 2. individuals with sars-cov-2 etiological testing (rt-pcr assay) (individuals with serological testing showing positive igg and/or igm antibodies may be enrolled); 3. individuals with a previous history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) and other human coronavirus infections or diseases; 4. individuals who have fever within 72 hours prior to dose 1 in this trial (oral temperature ≥38°c); 5. pregnant (e.g., positive pregnancy test) or lactating females; 6. individuals who have plan of pregnancy or interruption of effective contraceptive methods within 3 months after the second cross-vaccination in this study; 7. personnel of the study site or the sponsor; 8. individuals with prior history of allergic reaction or anaphylaxis to any vaccine or drug, e.g., hypersensitivity, urticaria, serious eczema, dyspnea, laryngeal edema, and angioedema etc.; 9. individuals who have been vaccinated with any vaccine other than the investigational vaccine used in this clinical trial from 28 days prior to dose 1 to 28 days after dose 2; 10. individuals who have participated in or plan to participate in other drug clinical trials form 28 days prior to dose 1 to 12 months after dose 4 (the second dose of cross-vaccination) in this study; 11. individuals who have hereditary hemorrhagic tendency or coagulation dysfunction (e.g., cytokine defects, coagulation disorders or platelet disorder), or a history of significant bleeding, or a history of injury caused by intramuscular injection or venipuncture; 12. individuals who are confirmed for diseases affecting immune system function, including cancer (except skin basal cell carcinoma), congenital or acquired immunodeficiency (e.g., infection with human immunodeficiency virus (hiv)), and uncontrolled autoimmune disease, based on known history or diagnosis; 13. individuals who have asplenia or functional asplenia; 14. individuals with long-term use (continuous use ≥14 days) of immunosuppressants or other immunomodulatory drugs (e.g., corticosteroids: prednisone or similar drugs) within 6 months prior to dose 1. drugs for topical use (e.g., ointment, eye drops, inhalants or nasal spray) are allowed in this study, and the topical medications should not exceed the recommended dose in the labels for use or induce any signs of systemic exposure; 15. individuals who have received immunoglobulin and/or blood products within 3 months prior to dose 1; 16. individuals who are suspected or known to have alcohol dependency problems or drug abuse that may affect safety evaluation or subject's compliance; 17. individuals who plan to permanently relocate from the local area before the completion of the study or leave the local area for long periods during the study visits; 18. other circumstances considered by the investigator as inappropriate to participate in the study. criteria for postponement of the subsequent doses: if the subjects have any of the followings prior to the subsequent doses, vaccination will be postponed. during the same immunization schedule, the second dose of vaccine will be administered at the 28th day after the first vaccination, with a time window of +5 days: 1. fever within 72 hours prior to the subsequent doses (oral temperature ≥38°c, probability of sars-cov-2 infection shall be excluded); 2. in case of acute diseases prior to the subsequent doses, the investigator shall exclude the probability of sars-cov-2 infection and evaluate the likelihood of short-term recovery for the diseases; exclusion criteria for the subsequent doses: if the subject has any of the followings prior to the subsequent doses, the vaccination shall be terminated for the subject while other study procedures could be continued at the discretion of the investigators: 1. female subjects of childbearing potential who have positive pregnancy test results; 2. subjects who have a serious allergic reaction or serious adverse event causally related to vaccination after previous vaccination; 3. other circumstances considered by the investigator as inappropriate to receive the subsequent doses of the vaccine. criteria for withdrawal from the study 1. subjects experience disability, life-threatening adverse events or serious adverse events and have to prematurely withdraw from this study due to treatment or other reasons. 2. subjects are placed at safety risks by their health conditions which prevent them from continuing to participate in this study. 3. female subjects become pregnant during the study (if at least one dose has been administered, the subject is not required to withdraw from this study but should not receive the subsequent doses. moreover, subsequent observation and follow-up visits should be continued); 4. subjects actively request to withdraw from the study; 5. subjects are considered unsuitable for continuing to participate in this study at the discretion of the investigator.

exclusion criteria for first dose vaccination subjects who meet any of the following exclusion criteria shall not be enrolled: individuals with a history of sars-cov-2 infection or use of any preventive products for covid-19 (e.g., a history of any sars-cov-2 vaccines that have or have not been marketed); individuals with sars-cov-2 etiological testing (rt-pcr assay) (individuals with serological testing showing positive igg and/or igm antibodies may be enrolled); individuals with a previous history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) and other human coronavirus infections or diseases; individuals who have fever within 72 hours prior to dose 1 in this trial (oral temperature ≥38°c); pregnant (e.g., positive pregnancy test) or lactating females; individuals who have plan of pregnancy or interruption of effective contraceptive methods within 3 months after the second cross-vaccination in this study; personnel of the study site or the sponsor; individuals with prior history of allergic reaction or anaphylaxis to any vaccine or drug, e.g., hypersensitivity, urticaria, serious eczema, dyspnea, laryngeal edema, and angioedema etc.; individuals who have been vaccinated with any vaccine other than the investigational vaccine used in this clinical trial from 28 days prior to dose 1 to 28 days after dose 2; individuals who have participated in or plan to participate in other drug clinical trials form 28 days prior to dose 1 to 12 months after dose 4 (the second dose of cross-vaccination) in this study; individuals who have hereditary hemorrhagic tendency or coagulation dysfunction (e.g., cytokine defects, coagulation disorders or platelet disorder), or a history of significant bleeding, or a history of injury caused by intramuscular injection or venipuncture; individuals who are confirmed for diseases affecting immune system function, including cancer (except skin basal cell carcinoma), congenital or acquired immunodeficiency (e.g., infection with human immunodeficiency virus (hiv)), and uncontrolled autoimmune disease, based on known history or diagnosis; individuals who have asplenia or functional asplenia; individuals with long-term use (continuous use ≥14 days) of immunosuppressants or other immunomodulatory drugs (e.g., corticosteroids: prednisone or similar drugs) within 6 months prior to dose 1. drugs for topical use (e.g., ointment, eye drops, inhalants or nasal spray) are allowed in this study, and the topical medications should not exceed the recommended dose in the labels for use or induce any signs of systemic exposure; individuals who have received immunoglobulin and/or blood products within 3 months prior to dose 1; individuals who are suspected or known to have alcohol dependency problems or drug abuse that may affect safety evaluation or subject's compliance; individuals who plan to permanently relocate from the local area before the completion of the study or leave the local area for long periods during the study visits; other circumstances considered by the investigator as inappropriate to participate in the study. criteria for postponement of the subsequent doses: if the subjects have any of the followings prior to the subsequent doses, vaccination will be postponed. during the same immunization schedule, the second dose of vaccine will be administered at the 28th day after the first vaccination, with a time window of +5 days: fever within 72 hours prior to the subsequent doses (oral temperature ≥38°c, probability of sars-cov-2 infection shall be excluded); in case of acute diseases prior to the subsequent doses, the investigator shall exclude the probability of sars-cov-2 infection and evaluate the likelihood of short-term recovery for the diseases; exclusion criteria for the subsequent doses: if the subject has any of the followings prior to the subsequent doses, the vaccination shall be terminated for the subject while other study procedures could be continued at the discretion of the investigators: female subjects of childbearing potential who have positive pregnancy test results; subjects who have a serious allergic reaction or serious adverse event causally related to vaccination after previous vaccination; other circumstances considered by the investigator as inappropriate to receive the subsequent doses of the vaccine. criteria for withdrawal from the study subjects experience disability, life-threatening adverse events or serious adverse events and have to prematurely withdraw from this study due to treatment or other reasons. subjects are placed at safety risks by their health conditions which prevent them from continuing to participate in this study. female subjects become pregnant during the study (if at least one dose has been administered, the subject is not required to withdraw from this study but should not receive the subsequent doses. moreover, subsequent observation and follow-up visits should be continued); subjects actively request to withdraw from the study; subjects are considered unsuitable for continuing to participate in this study at the discretion of the investigator.

exclusion criteria for first dose vaccination subjects who meet any of the following exclusion criteria shall not be enrolled: individuals with a history of sars-cov-2 infection or use of any preventive products for covid-19 (e.g., a history of any sars-cov-2 vaccines that have or have not been marketed); individuals with sars-cov-2 etiological testing (rt-pcr assay) (individuals with serological testing showing positive igg and/or igm antibodies may be enrolled); individuals with a previous history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) and other human coronavirus infections or diseases; individuals who have fever within 72 hours prior to dose 1 in this trial (oral temperature ≥38°c); pregnant (e.g., positive pregnancy test) or lactating females; individuals who have plan of pregnancy or interruption of effective contraceptive methods within 3 months after the second cross-vaccination in this study; personnel of the study site or the sponsor; individuals with prior history of allergic reaction or anaphylaxis to any vaccine or drug, e.g., hypersensitivity, urticaria, serious eczema, dyspnea, laryngeal edema, and angioedema etc.; individuals who have been vaccinated with any vaccine other than the investigational vaccine used in this clinical trial from 28 days prior to dose 1 to 28 days after dose 2; individuals who have participated in or plan to participate in other drug clinical trials form 28 days prior to dose 1 to 12 months after dose 4 (the second dose of cross-vaccination) in this study; individuals who have hereditary hemorrhagic tendency or coagulation dysfunction (e.g., cytokine defects, coagulation disorders or platelet disorder), or a history of significant bleeding, or a history of injury caused by intramuscular injection or venipuncture; individuals who are confirmed for diseases affecting immune system function, including cancer (except skin basal cell carcinoma), congenital or acquired immunodeficiency (e.g., infection with human immunodeficiency virus (hiv)), and uncontrolled autoimmune disease, based on known history or diagnosis; individuals who have asplenia or functional asplenia; individuals with long-term use (continuous use ≥14 days) of immunosuppressants or other immunomodulatory drugs (e.g., corticosteroids: prednisone or similar drugs) within 6 months prior to dose 1. drugs for topical use (e.g., ointment, eye drops, inhalants or nasal spray) are allowed in this study, and the topical medications should not exceed the recommended dose in the labels for use or induce any signs of systemic exposure; individuals who have received immunoglobulin and/or blood products within 3 months prior to dose 1; individuals who are suspected or known to have alcohol dependency problems or drug abuse that may affect safety evaluation or subject's compliance; individuals who plan to permanently relocate from the local area before the completion of the study or leave the local area for long periods during the study visits; other circumstances considered by the investigator as inappropriate to participate in the study. criteria for postponement of the subsequent doses: if the subjects have any of the followings prior to the subsequent doses, vaccination will be postponed. during the same immunization schedule, the second dose of vaccine will be administered at the 28th day after the first vaccination, with a time window of +5 days: fever within 72 hours prior to the subsequent doses (oral temperature ≥38°c, probability of sars-cov-2 infection shall be excluded); in case of acute diseases prior to the subsequent doses, the investigator shall exclude the probability of sars-cov-2 infection and evaluate the likelihood of short-term recovery for the diseases; exclusion criteria for the subsequent doses: if the subject has any of the followings prior to the subsequent doses, the vaccination shall be terminated for the subject while other study procedures could be continued at the discretion of the investigators: female subjects of childbearing potential who have positive pregnancy test results; subjects who have a serious allergic reaction or serious adverse event causally related to vaccination after previous vaccination; other circumstances considered by the investigator as inappropriate to receive the subsequent doses of the vaccine. criteria for withdrawal from the study subjects experience disability, life-threatening adverse events or serious adverse events and have to prematurely withdraw from this study due to treatment or other reasons. subjects are placed at safety risks by their health conditions which prevent them from continuing to participate in this study. female subjects become pregnant during the study (if at least one dose has been administered, the subject is not required to withdraw from this study but should not receive the subsequent doses. moreover, subsequent observation and follow-up visits should be continued); subjects actively request to withdraw from the study; subjects are considered unsuitable for continuing to participate in this study at the discretion of the investigator.

exclusion criteria for first dose vaccination subjects who meet any of the following exclusion criteria shall not be enrolled: 1. individuals with a history of sars-cov-2 infection or use of any preventive products for covid-19 (e.g., a history of any sars-cov-2 vaccines that have or have not been marketed); 2. individuals with sars-cov-2 etiological testing (rt-pcr assay) (individuals with serological testing showing positive igg and/or igm antibodies may be enrolled); 3. individuals with a previous history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) and other human coronavirus infections or diseases; 4. individuals who have fever within 72 hours prior to dose 1 in this trial (oral temperature ≥38°c); 5. pregnant (e.g., positive pregnancy test) or lactating females; 6. individuals who have plan of pregnancy or interruption of effective contraceptive methods within 3 months after the second cross-vaccination in this study; 7. personnel of the study site or the sponsor; 8. individuals with prior history of allergic reaction or anaphylaxis to any vaccine or drug, e.g., hypersensitivity, urticaria, serious eczema, dyspnea, laryngeal edema, and angioedema etc.; 9. individuals who have been vaccinated with any vaccine other than the investigational vaccine used in this clinical trial from 28 days prior to dose 1 to 28 days after dose 2; 10. individuals who have participated in or plan to participate in other drug clinical trials form 28 days prior to dose 1 to 12 months after dose 4 (the second dose of cross-vaccination) in this study; 11. individuals who have hereditary hemorrhagic tendency or coagulation dysfunction (e.g., cytokine defects, coagulation disorders or platelet disorder), or a history of significant bleeding, or a history of injury caused by intramuscular injection or venipuncture; 12. individuals who are confirmed for diseases affecting immune system function, including cancer (except skin basal cell carcinoma), congenital or acquired immunodeficiency (e.g., infection with human immunodeficiency virus (hiv)), and uncontrolled autoimmune disease, based on known history or diagnosis; 13. individuals who have asplenia or functional asplenia; 14. individuals with long-term use (continuous use ≥14 days) of immunosuppressants or other immunomodulatory drugs (e.g., corticosteroids: prednisone or similar drugs) within 6 months prior to dose 1. drugs for topical use (e.g., ointment, eye drops, inhalants or nasal spray) are allowed in this study, and the topical medications should not exceed the recommended dose in the labels for use or induce any signs of systemic exposure; 15. individuals who have received immunoglobulin and/or blood products within 3 months prior to dose 1; 16. individuals who are suspected or known to have alcohol dependency problems or drug abuse that may affect safety evaluation or subject's compliance; 17. individuals who plan to permanently relocate from the local area before the completion of the study or leave the local area for long periods during the study visits; 18. other circumstances considered by the investigator as inappropriate to participate in the study. criteria for postponement of the subsequent doses: if the subjects have any of the followings prior to the subsequent doses, vaccination will be postponed. during the same immunization schedule, the second dose of vaccine will be administered at the 28th day after the first vaccination, with a time window of +5 days: 1. fever within 72 hours prior to the subsequent doses (oral temperature ≥38°c, probability of sars-cov-2 infection shall be excluded); 2. in case of acute diseases prior to the subsequent doses, the investigator shall exclude the probability of sars-cov-2 infection and evaluate the likelihood of short-term recovery for the diseases; exclusion criteria for the subsequent doses: if the subject has any of the followings prior to the subsequent doses, the vaccination shall be terminated for the subject while other study procedures could be continued at the discretion of the investigators: 1. female subjects of childbearing potential who have positive pregnancy test results; 2. subjects who have a serious allergic reaction or serious adverse event causally related to vaccination after previous vaccination; 3. other circumstances considered by the investigator as inappropriate to receive the subsequent doses of the vaccine. criteria for withdrawal from the study 1. subjects experience disability, life-threatening adverse events or serious adverse events and have to prematurely withdraw from this study due to treatment or other reasons. 2. subjects are placed at safety risks by their health conditions which prevent them from continuing to participate in this study. 3. female subjects become pregnant during the study (if at least one dose has been administered, the subject is not required to withdraw from this study but should not receive the subsequent doses. moreover, subsequent observation and follow-up visits should be continued); 4. subjects actively request to withdraw from the study; 5. subjects are considered unsuitable for continuing to participate in this study at the discretion of the investigator.

exclusion criteria for first dose vaccination subjects who meet any of the following exclusion criteria shall not be enrolled: 1. individuals with a history of sars-cov-2 infection or use of any preventive products for covid-19 (e.g., a history of any sars-cov-2 vaccines that have or have not been marketed); 2. individuals with sars-cov-2 etiological testing (rt-pcr assay) (individuals with serological testing showing positive igg and/or igm antibodies may be enrolled); 3. individuals with a previous history of severe acute respiratory syndrome (sars), middle east respiratory syndrome (mers) and other human coronavirus infections or diseases; 4. individuals who have fever within 72 hours prior to dose 1 in this trial (oral temperature ≥38°c); 5. pregnant (e.g., positive pregnancy test) or lactating females; 6. individuals who have plan of pregnancy or interruption of effective contraceptive methods within 3 months after the second cross-vaccination in this study; 7. personnel of the study site or the sponsor; 8. individuals with prior history of allergic reaction or anaphylaxis to any vaccine or drug, e.g., hypersensitivity, urticaria, serious eczema, dyspnea, laryngeal edema, and angioedema etc.; 9. individuals who have been vaccinated with any vaccine other than the investigational vaccine used in this clinical trial from 28 days prior to dose 1 to 28 days after dose 2; 10. individuals who have participated in or plan to participate in other drug clinical trials form 28 days prior to dose 1 to 12 months after dose 4 (the second dose of cross-vaccination) in this study; 11. individuals who have hereditary hemorrhagic tendency or coagulation dysfunction (e.g., cytokine defects, coagulation disorders or platelet disorder), or a history of significant bleeding, or a history of injury caused by intramuscular injection or venipuncture; 12. individuals who are confirmed for diseases affecting immune system function, including cancer (except skin basal cell carcinoma), congenital or acquired immunodeficiency (e.g., infection with human immunodeficiency virus (hiv)), and uncontrolled autoimmune disease, based on known history or diagnosis; 13. individuals who have asplenia or functional asplenia; 14. individuals with long-term use (continuous use ≥14 days) of immunosuppressants or other immunomodulatory drugs (e.g., corticosteroids: prednisone or similar drugs) within 6 months prior to dose 1. drugs for topical use (e.g., ointment, eye drops, inhalants or nasal spray) are allowed in this study, and the topical medications should not exceed the recommended dose in the labels for use or induce any signs of systemic exposure; 15. individuals who have received immunoglobulin and/or blood products within 3 months prior to dose 1; 16. individuals who are suspected or known to have alcohol dependency problems or drug abuse that may affect safety evaluation or subject's compliance; 17. individuals who plan to permanently relocate from the local area before the completion of the study or leave the local area for long periods during the study visits; 18. other circumstances considered by the investigator as inappropriate to participate in the study. criteria for postponement of the subsequent doses: if the subjects have any of the followings prior to the subsequent doses, vaccination will be postponed. during the same immunization schedule, the second dose of vaccine will be administered at the 28th day after the first vaccination, with a time window of +5 days: 1. fever within 72 hours prior to the subsequent doses (oral temperature ≥38°c, probability of sars-cov-2 infection shall be excluded); 2. in case of acute diseases prior to the subsequent doses, the investigator shall exclude the probability of sars-cov-2 infection and evaluate the likelihood of short-term recovery for the diseases; exclusion criteria for the subsequent doses: if the subject has any of the followings prior to the subsequent doses, the vaccination shall be terminated for the subject while other study procedures could be continued at the discretion of the investigators: 1. female subjects of childbearing potential who have positive pregnancy test results; 2. subjects who have a serious allergic reaction or serious adverse event causally related to vaccination after previous vaccination; 3. other circumstances considered by the investigator as inappropriate to receive the subsequent doses of the vaccine. criteria for withdrawal from the study 1. subjects experience disability, life-threatening adverse events or serious adverse events and have to prematurely withdraw from this study due to treatment or other reasons. 2. subjects are placed at safety risks by their health conditions which prevent them from continuing to participate in this study. 3. female subjects become pregnant during the study (if at least one dose has been administered, the subject is not required to withdraw from this study but should not receive the subsequent doses. moreover, subsequent observation and follow-up visits should be continued); 4. subjects actively request to withdraw from the study; 5. subjects are considered unsuitable for continuing to participate in this study at the discretion of the investigator.