1. more than 72 hours from the onset of ards. 2. age \< 16 years. 3. patient is known to be pregnant 4. major trauma in the prior 3 days. 5. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. 6. who class iii or iv pulmonary hypertension. 7. venous thromboembolism currently receiving anti-coagulation or within the past 3 months 8. currently receiving extracorporeal life support (ecls). 9. severe chronic liver disease with child-pugh score \> 12. 10. dnar (do not attempt resuscitation) order (excluding advance directives) in place. 11. treatment withdrawal imminent within 24 hours. 12. consent declined. 13. prisoners. 14. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. 15. previously enrolled in the realist trial.

1. more than 72 hours from the onset of ards. 2. age \< 16 years. 3. patient is known to be pregnant 4. major trauma in the prior 3 days. 5. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. 6. who class iii or iv pulmonary hypertension. 7. venous thromboembolism currently receiving anti-coagulation or within the past 3 months 8. currently receiving extracorporeal life support (ecls). 9. severe chronic liver disease with child-pugh score \> 12. 10. dnar (do not attempt resuscitation) order (excluding advance directives) in place. 11. treatment withdrawal imminent within 24 hours. 12. consent declined. 13. prisoners. 14. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. 15. previously enrolled in the realist trial.

more than 72 hours from the onset of ards. age < 16 years. patient is known to be pregnant major trauma in the prior 3 days. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. who class iii or iv pulmonary hypertension. venous thromboembolism currently receiving anti-coagulation or within the past 3 months currently receiving extracorporeal life support (ecls). severe chronic liver disease with child-pugh score > 12. dnar (do not attempt resuscitation) order (excluding advance directives) in place. treatment withdrawal imminent within 24 hours. consent declined. prisoners. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. previously enrolled in the realist trial.

more than 72 hours from the onset of ards. age < 16 years. patient is known to be pregnant major trauma in the prior 3 days. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. who class iii or iv pulmonary hypertension. venous thromboembolism currently receiving anti-coagulation or within the past 3 months currently receiving extracorporeal life support (ecls). severe chronic liver disease with child-pugh score > 12. dnar (do not attempt resuscitation) order (excluding advance directives) in place. treatment withdrawal imminent within 24 hours. consent declined. prisoners. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. previously enrolled in the realist trial.

more than 72 hours from the onset of ards. age < 16 years. patient is known to be pregnant major trauma in the prior 5 days. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. who class iii or iv pulmonary hypertension. venous thromboembolism currently receiving anti-coagulation or within the past 3 months currently receiving extracorporeal life support (ecls). severe chronic liver disease with child-pugh score > 12. dnar (do not attempt resuscitation) order in place. treatment withdrawal imminent within 24 hours. consent declined. prisoners. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. previously enrolled in the realist trial.

more than 72 hours from the onset of ards. age < 16 years. patient is known to be pregnant major trauma in the prior 5 days. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. who class iii or iv pulmonary hypertension. venous thromboembolism currently receiving anti-coagulation or within the past 3 months currently receiving extracorporeal life support (ecls). severe chronic liver disease with child-pugh score > 12. dnar (do not attempt resuscitation) order in place. treatment withdrawal imminent within 24 hours. consent declined. prisoners. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. previously enrolled in the realist trial.

1. more than 72 hours from the onset of ards. 2. age < 16 years. 3. patient is known to be pregnant 4. major trauma in the prior 5 days. 5. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. 6. who class iii or iv pulmonary hypertension. 7. venous thromboembolism currently receiving anti-coagulation or within the past 3 months 8. currently receiving extracorporeal life support (ecls). 9. severe chronic liver disease with child-pugh score > 12. 10. dnar (do not attempt resuscitation) order in place. 11. treatment withdrawal imminent within 24 hours. 12. consent declined. 13. prisoners. 14. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. 15. previously enrolled in the realist trial.

1. more than 72 hours from the onset of ards. 2. age < 16 years. 3. patient is known to be pregnant 4. major trauma in the prior 5 days. 5. presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last year. 6. who class iii or iv pulmonary hypertension. 7. venous thromboembolism currently receiving anti-coagulation or within the past 3 months 8. currently receiving extracorporeal life support (ecls). 9. severe chronic liver disease with child-pugh score > 12. 10. dnar (do not attempt resuscitation) order in place. 11. treatment withdrawal imminent within 24 hours. 12. consent declined. 13. prisoners. 14. non-english speaking patients or those who do not adequately understand verbal or written information unless an interpreter is available. 15. previously enrolled in the realist trial.