inclusion criteria: * written informed consent * age above 18 years * women of childbearing age only: must agree to practice continuous effective contraception for the duration of the study (a method which results in a failure rate less than 1% per year) * disease severe enough to require hospitalization * qtc interval lower than 450 msec

inclusion criteria: * written informed consent * age above 18 years * women of childbearing age only: must agree to practice continuous effective contraception for the duration of the study (a method which results in a failure rate less than 1% per year) * disease severe enough to require hospitalization * qtc interval lower than 450 msec

inclusion criteria: - written informed consent - age above 18 years - women of childbearing age only: must agree to practice continuous effective contraception for the duration of the study (a method which results in a failure rate less than 1% per year) - disease severe enough to require hospitalization - qtc interval lower than 450 msec

inclusion criteria: - written informed consent - age above 18 years - women of childbearing age only: must agree to practice continuous effective contraception for the duration of the study (a method which results in a failure rate less than 1% per year) - disease severe enough to require hospitalization - qtc interval lower than 450 msec