None

None

- acutely ill 72 hours prior to or at screening. volunteers meeting this criterion may be rescheduled within the relevant window periods. participants with minor illnesses can be enrolled at the discretion of the investigator. - blood products, systemic immunoglobulins, or monoclonal antibodies (including against sars-cov-2) received within 90 days before first vaccination. - investigational research agents received within 30 days before first vaccination. - self-reported known history of sars-cov-2 infection. - prior administration of a coronavirus (sars-cov-2, sars-cov, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19. - immunosuppressive medications received within 168 days before first vaccination (not exclusionary: [1] corticosteroid nasal spray; [2] inhaled corticosteroids; [3] topical corticosteroids for mild, uncomplicated dermatologic condition; or [4] a single course of oral/parenteral prednisone or equivalent at doses < 60 mg/day and length of therapy < 11 days with completion at least 30 days prior to enrollment). - clinically significant medical condition, physical examination findings, or past medical history with clinically significant implications for current health. a clinically significant condition or process includes but is not limited to a process that would affect the immune response (well-controlled human immunodeficiency virus infection is allowed), or any condition specifically listed among the exclusion criteria below. - any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, assessment of safety or reactogenicity, or a volunteer's ability to give informed consent. - bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder requiring special precautions). - asplenia: any condition resulting in the absence of a functional spleen. - history of angioedema or anaphylaxis, including to vaccines or vaccine components (not exclusionary: angioedema or anaphylaxis with known trigger and no episodes within five years.). - history of generalized urticaria within past five years.

- acutely ill 72 hours prior to or at screening. volunteers meeting this criterion may be rescheduled within the relevant window periods. participants with minor illnesses can be enrolled at the discretion of the investigator. - blood products, systemic immunoglobulins, or monoclonal antibodies (including against sars-cov-2) received within 90 days before first vaccination. - investigational research agents received within 30 days before first vaccination. - self-reported known history of sars-cov-2 infection. - prior administration of a coronavirus (sars-cov-2, sars-cov, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19. - immunosuppressive medications received within 168 days before first vaccination (not exclusionary: [1] corticosteroid nasal spray; [2] inhaled corticosteroids; [3] topical corticosteroids for mild, uncomplicated dermatologic condition; or [4] a single course of oral/parenteral prednisone or equivalent at doses < 60 mg/day and length of therapy < 11 days with completion at least 30 days prior to enrollment). - clinically significant medical condition, physical examination findings, or past medical history with clinically significant implications for current health. a clinically significant condition or process includes but is not limited to a process that would affect the immune response (well-controlled human immunodeficiency virus infection is allowed), or any condition specifically listed among the exclusion criteria below. - any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, assessment of safety or reactogenicity, or a volunteer's ability to give informed consent. - bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder requiring special precautions). - asplenia: any condition resulting in the absence of a functional spleen. - history of angioedema or anaphylaxis, including to vaccines or vaccine components (not exclusionary: angioedema or anaphylaxis with known trigger and no episodes within five years.). - history of generalized urticaria within past five years.

- acutely ill or febrile 72 hours prior to or at screening. fever is defined as a body temperature ≥ 38.0°c/100.4°f. volunteers meeting this criterion may be rescheduled within the relevant window periods. afebrile participants with minor illnesses can be enrolled at the discretion of the investigator. - blood products, systemic immunoglobulins, or monoclonal antibodies (including against sars-cov-2) received within 90 days before first vaccination. - investigational research agents received within 30 days before first vaccination. - self-reported known history of sars-cov-2 infection. - prior administration of a coronavirus (sars-cov-2, sars-cov, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19. - immunosuppressive medications received within 168 days before first vaccination (not exclusionary: [1] corticosteroid nasal spray; [2] inhaled corticosteroids; [3] topical corticosteroids for mild, uncomplicated dermatologic condition; or [4] a single course of oral/parenteral prednisone or equivalent at doses < 60 mg/day and length of therapy < 11 days with completion at least 30 days prior to enrollment). - clinically significant medical condition, physical examination findings, or past medical history with clinically significant implications for current health. a clinically significant condition or process includes but is not limited to a process that would affect the immune response (well-controlled human immunodeficiency virus infection is allowed), or any condition specifically listed among the exclusion criteria below. - any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, assessment of safety or reactogenicity, or a volunteer's ability to give informed consent. - bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder requiring special precautions). - asplenia: any condition resulting in the absence of a functional spleen. - history of angioedema or anaphylaxis, including to vaccines or vaccine components (not exclusionary: angioedema or anaphylaxis with known trigger and no episodes within five years.). - history of generalized urticaria within past five years.

- acutely ill or febrile 72 hours prior to or at screening. fever is defined as a body temperature ≥ 38.0°c/100.4°f. volunteers meeting this criterion may be rescheduled within the relevant window periods. afebrile participants with minor illnesses can be enrolled at the discretion of the investigator. - blood products, systemic immunoglobulins, or monoclonal antibodies (including against sars-cov-2) received within 90 days before first vaccination. - investigational research agents received within 30 days before first vaccination. - self-reported known history of sars-cov-2 infection. - prior administration of a coronavirus (sars-cov-2, sars-cov, mers-cov) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat covid-19. - immunosuppressive medications received within 168 days before first vaccination (not exclusionary: [1] corticosteroid nasal spray; [2] inhaled corticosteroids; [3] topical corticosteroids for mild, uncomplicated dermatologic condition; or [4] a single course of oral/parenteral prednisone or equivalent at doses < 60 mg/day and length of therapy < 11 days with completion at least 30 days prior to enrollment). - clinically significant medical condition, physical examination findings, or past medical history with clinically significant implications for current health. a clinically significant condition or process includes but is not limited to a process that would affect the immune response (well-controlled human immunodeficiency virus infection is allowed), or any condition specifically listed among the exclusion criteria below. - any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, assessment of safety or reactogenicity, or a volunteer's ability to give informed consent. - bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder requiring special precautions). - asplenia: any condition resulting in the absence of a functional spleen. - history of angioedema or anaphylaxis, including to vaccines or vaccine components (not exclusionary: angioedema or anaphylaxis with known trigger and no episodes within five years.). - history of generalized urticaria within past five years.