inclusion criteria: 1. individuals 18 years of age or older on the day of informed consent. 2. individuals who have voluntarily given written informed consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry. 3. individuals who can comply with study procedures including follow-up . 4. females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days after the last study vaccination.

inclusion criteria: 1. individuals 18 years of age or older on the day of informed consent. 2. individuals who have voluntarily given written informed consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry. 3. individuals who can comply with study procedures including follow-up . 4. females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days after the last study vaccination.

inclusion criteria: individuals 18 years of age or older on the day of informed consent. individuals who have voluntarily given written informed consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry. individuals who can comply with study procedures including follow-up . females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days after the last study vaccination.

inclusion criteria: individuals 18 years of age or older on the day of informed consent. individuals who have voluntarily given written informed consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry. individuals who can comply with study procedures including follow-up . females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days after the last study vaccination.

inclusion criteria: 1. individuals 18 years of age or older on the day of informed consent. 2. individuals who have voluntarily given written informed consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry. 3. individuals who can comply with study procedures including follow-up . 4. females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days after the last study vaccination.

inclusion criteria: 1. individuals 18 years of age or older on the day of informed consent. 2. individuals who have voluntarily given written informed consent after the nature of the study has been explained according to local regulatory requirements, prior to study entry. 3. individuals who can comply with study procedures including follow-up . 4. females of non-childbearing potential or females of childbearing potential who are using an effective birth control method which they intend to use for at least 30 days after the last study vaccination.