* contraindication or allergy to chloroquine, hydroxychloroquine or azithromycin * current use hydroxychloroquine, chloroquine or azithromycin * concurrent use of another investigational agent * invasive mechanical ventilation * participants who have any severe and/or uncontrolled medical conditions such as: * unstable angina pectoris, * symptomatic congestive heart failure, * myocardial infarction, * cardiac arrhythmias or know prolonged qtc \>470 males, \>480 female on ecg * pulmonary insufficiency, * epilepsy (interaction with chloroquine), * prior retinal eye disease * concurrent malignancy requiring chemotherapy * known chronic kidney disease, egfr\<10 or dialysis * g-6-pd deficiency, if unknown requires g6pd testing prior to enrollment * known porphyria * known myasthenia gravis * currently pregnant or planning on getting pregnant while on study * breast feeding * ast/alt \>five times the upper limit of normal uln\* * bilirubin \>five times the uln\* * magnesium \<1.4 meq/l\* * calcium \<8.4mg/dl \>10.6mg/dl\* * potassium \<3.3 \>5.5 meg/l\*

* contraindication or allergy to chloroquine, hydroxychloroquine or azithromycin * current use hydroxychloroquine, chloroquine or azithromycin * concurrent use of another investigational agent * invasive mechanical ventilation * participants who have any severe and/or uncontrolled medical conditions such as: * unstable angina pectoris, * symptomatic congestive heart failure, * myocardial infarction, * cardiac arrhythmias or know prolonged qtc \>470 males, \>480 female on ecg * pulmonary insufficiency, * epilepsy (interaction with chloroquine), * prior retinal eye disease * concurrent malignancy requiring chemotherapy * known chronic kidney disease, egfr\<10 or dialysis * g-6-pd deficiency, if unknown requires g6pd testing prior to enrollment * known porphyria * known myasthenia gravis * currently pregnant or planning on getting pregnant while on study * breast feeding * ast/alt \>five times the upper limit of normal uln\* * bilirubin \>five times the uln\* * magnesium \<1.4 meq/l\* * calcium \<8.4mg/dl \>10.6mg/dl\* * potassium \<3.3 \>5.5 meg/l\*

- contraindication or allergy to chloroquine, hydroxychloroquine or azithromycin - current use hydroxychloroquine, chloroquine or azithromycin - concurrent use of another investigational agent - invasive mechanical ventilation - participants who have any severe and/or uncontrolled medical conditions such as: - unstable angina pectoris, - symptomatic congestive heart failure, - myocardial infarction, - cardiac arrhythmias or know prolonged qtc >470 males, >480 female on ecg - pulmonary insufficiency, - epilepsy (interaction with chloroquine), - prior retinal eye disease - concurrent malignancy requiring chemotherapy - known chronic kidney disease, egfr<10 or dialysis - g-6-pd deficiency, if unknown requires g6pd testing prior to enrollment - known porphyria - known myasthenia gravis - currently pregnant or planning on getting pregnant while on study - breast feeding - ast/alt >five times the upper limit of normal uln* - bilirubin >five times the uln* - magnesium <1.4 meq/l* - calcium <8.4mg/dl >10.6mg/dl* - potassium <3.3 >5.5 meg/l*

- contraindication or allergy to chloroquine, hydroxychloroquine or azithromycin - current use hydroxychloroquine, chloroquine or azithromycin - concurrent use of another investigational agent - invasive mechanical ventilation - participants who have any severe and/or uncontrolled medical conditions such as: - unstable angina pectoris, - symptomatic congestive heart failure, - myocardial infarction, - cardiac arrhythmias or know prolonged qtc >470 males, >480 female on ecg - pulmonary insufficiency, - epilepsy (interaction with chloroquine), - prior retinal eye disease - concurrent malignancy requiring chemotherapy - known chronic kidney disease, egfr<10 or dialysis - g-6-pd deficiency, if unknown requires g6pd testing prior to enrollment - known porphyria - known myasthenia gravis - currently pregnant or planning on getting pregnant while on study - breast feeding - ast/alt >five times the upper limit of normal uln* - bilirubin >five times the uln* - magnesium <1.4 meq/l* - calcium <8.4mg/dl >10.6mg/dl* - potassium <3.3 >5.5 meg/l*