inclusion criteria: * aged \>= 18 years on the day of inclusion. * a female participant was eligible to participate if she was not pregnant or breastfeeding and one of the following conditions applies: * was of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or * was of childbearing potential and agreed to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must had a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before the study intervention. * informed consent form had been signed and dated. * participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria: * aged \>= 18 years on the day of inclusion. * a female participant was eligible to participate if she was not pregnant or breastfeeding and one of the following conditions applies: * was of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or * was of childbearing potential and agreed to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must had a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before the study intervention. * informed consent form had been signed and dated. * participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria: aged >= 18 years on the day of inclusion. a female participant was eligible to participate if she was not pregnant or breastfeeding and one of the following conditions applies: was of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or was of childbearing potential and agreed to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must had a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before the study intervention. informed consent form had been signed and dated. participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria: aged >= 18 years on the day of inclusion. a female participant was eligible to participate if she was not pregnant or breastfeeding and one of the following conditions applies: was of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or was of childbearing potential and agreed to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must had a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before the study intervention. informed consent form had been signed and dated. participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria : - aged ≥ 18 years on the day of inclusion. - a female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies: - is of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or - is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before the study intervention. - informed consent form has been signed and dated. - participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria : - aged ≥ 18 years on the day of inclusion. - a female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies: - is of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or - is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before the study intervention. - informed consent form has been signed and dated. - participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria : - aged ≥ 18 years on the day of inclusion. - a female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies: - is of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or - is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before any dose of study intervention. - informed consent form has been signed and dated. - participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.

inclusion criteria : - aged ≥ 18 years on the day of inclusion. - a female participant is eligible to participate if she is not pregnant or breastfeeding and one of the following conditions applies: - is of non-childbearing potential. to be considered of non-childbearing potential, a female must be pre-menarche or post-menopausal for at least 1 year, or surgically sterile. or - is of childbearing potential and agrees to use an effective contraceptive method or abstinence from at least 4 weeks prior to the first vaccination until at least 12 weeks after the last vaccination. a participant of childbearing potential must have a negative highly sensitive pregnancy test (urine or serum as required by local regulation) within 8 hours before any dose of study intervention. - informed consent form has been signed and dated. - participant not eligible to receive, based on local guidance, or if eligible does not intend to receive an authorized/approved covid-19 vaccine from first vaccination until completion of the key timepoint of day 43 of follow-up of this study.