inclusion criteria: * age ≥ 18 years; * moderate-severe ards, as defined by berlin definition for ards (onset within 1 week of a known clinical insult or new or worsening respiratory symptoms, bilateral opacities not fully explained by effusions, lobar/lung collapse, or nodules, respiratory failure not fully explained by cardiac failure or fluid overload and p/f ratio ≤200 mmhg with peep ≥5 cmh2o), and intubated for mechanical ventilation. * pcr positive for sars-cov2 within the current disease episode. * provision of signed written informed consent from the patient or patient's legally authorised representative;

inclusion criteria: * age ≥ 18 years; * moderate-severe ards, as defined by berlin definition for ards (onset within 1 week of a known clinical insult or new or worsening respiratory symptoms, bilateral opacities not fully explained by effusions, lobar/lung collapse, or nodules, respiratory failure not fully explained by cardiac failure or fluid overload and p/f ratio ≤200 mmhg with peep ≥5 cmh2o), and intubated for mechanical ventilation. * pcr positive for sars-cov2 within the current disease episode. * provision of signed written informed consent from the patient or patient's legally authorised representative;

inclusion criteria: - age ≥ 18 years; - moderate-severe ards, as defined by berlin definition for ards (onset within 1 week of a known clinical insult or new or worsening respiratory symptoms, bilateral opacities not fully explained by effusions, lobar/lung collapse, or nodules, respiratory failure not fully explained by cardiac failure or fluid overload and p/f ratio ≤200 mmhg with peep ≥5 cmh2o), and intubated for mechanical ventilation. - pcr positive for sars-cov2 within the current disease episode. - provision of signed written informed consent from the patient or patient's legally authorised representative;

inclusion criteria: - age ≥ 18 years; - moderate-severe ards, as defined by berlin definition for ards (onset within 1 week of a known clinical insult or new or worsening respiratory symptoms, bilateral opacities not fully explained by effusions, lobar/lung collapse, or nodules, respiratory failure not fully explained by cardiac failure or fluid overload and p/f ratio ≤200 mmhg with peep ≥5 cmh2o), and intubated for mechanical ventilation. - pcr positive for sars-cov2 within the current disease episode. - provision of signed written informed consent from the patient or patient's legally authorised representative;