* prior vaccination for covid-19; * diagnosis of covid-19 in the last 28 days (nasal and oropharyngeal swab); * history of severe allergic reaction or anaphylaxis to study vaccine components; * report of fever in the 72 hours prior to vaccination (the inclusion may be postponed until the participant completes 72 hours without fever); * possible or confirmed of covid-19 on the day of vaccination (in this situation, vaccination can be postponed until the participant completes 72 hours without symptoms or the diagnosis is ruled out); * have received live attenuated virus vaccine in the last 28 days or inactivated vaccine in the last 14 days prior to inclusion in the study, or have immunization scheduled for the first 28 days after their inclusion in the study; * any other condition that, in the opinion of the principal investigator or his medical representative, could endanger the safety or rights of a potential participant or that would prevent him or her from complying with this protocol; * pregnancy or breastfeeding.

* prior vaccination for covid-19; * diagnosis of covid-19 in the last 28 days (nasal and oropharyngeal swab); * history of severe allergic reaction or anaphylaxis to study vaccine components; * report of fever in the 72 hours prior to vaccination (the inclusion may be postponed until the participant completes 72 hours without fever); * possible or confirmed of covid-19 on the day of vaccination (in this situation, vaccination can be postponed until the participant completes 72 hours without symptoms or the diagnosis is ruled out); * have received live attenuated virus vaccine in the last 28 days or inactivated vaccine in the last 14 days prior to inclusion in the study, or have immunization scheduled for the first 28 days after their inclusion in the study; * any other condition that, in the opinion of the principal investigator or his medical representative, could endanger the safety or rights of a potential participant or that would prevent him or her from complying with this protocol; * pregnancy or breastfeeding.

- prior vaccination for covid-19; - diagnosis of covid-19 in the last 28 days (nasal and oropharyngeal swab); - history of severe allergic reaction or anaphylaxis to study vaccine components; - report of fever in the 72 hours prior to vaccination (the inclusion may be postponed until the participant completes 72 hours without fever); - possible or confirmed of covid-19 on the day of vaccination (in this situation, vaccination can be postponed until the participant completes 72 hours without symptoms or the diagnosis is ruled out); - have received live attenuated virus vaccine in the last 28 days or inactivated vaccine in the last 14 days prior to inclusion in the study, or have immunization scheduled for the first 28 days after their inclusion in the study; - any other condition that, in the opinion of the principal investigator or his medical representative, could endanger the safety or rights of a potential participant or that would prevent him or her from complying with this protocol; - pregnancy or breastfeeding.

- prior vaccination for covid-19; - diagnosis of covid-19 in the last 28 days (nasal and oropharyngeal swab); - history of severe allergic reaction or anaphylaxis to study vaccine components; - report of fever in the 72 hours prior to vaccination (the inclusion may be postponed until the participant completes 72 hours without fever); - possible or confirmed of covid-19 on the day of vaccination (in this situation, vaccination can be postponed until the participant completes 72 hours without symptoms or the diagnosis is ruled out); - have received live attenuated virus vaccine in the last 28 days or inactivated vaccine in the last 14 days prior to inclusion in the study, or have immunization scheduled for the first 28 days after their inclusion in the study; - any other condition that, in the opinion of the principal investigator or his medical representative, could endanger the safety or rights of a potential participant or that would prevent him or her from complying with this protocol; - pregnancy or breastfeeding.

- previous vaccination against covid-19; - diagnosis of covid-19 in the last 28 days (nasal and oropharyngeal swab); - history of severe allergic reaction or anaphylaxis to study vaccine components; - report of fever in the 72 hours preceding vaccination (the inclusion can be postponed until the participant completes 72 hours without fever); - possible or confirmed of covid-19 on the day of vaccination (in this situation, vaccination can be postponed until the participant completes 72 hours without symptoms or the diagnosis is ruled out); - have received vaccine with live attenuated virus in the last 28 days or inactivated vaccine in the last 14 days prior to their inclusion in the study, or have immunization scheduled for the first 28 days after their inclusion in the study; - any other condition that, in the opinion of the principal investigator or his medical representative, could jeopardize the safety or rights of a potential participant or that would prevent him from complying with this protocol; - pregnancy or lactating.

- previous vaccination against covid-19; - diagnosis of covid-19 in the last 28 days (nasal and oropharyngeal swab); - history of severe allergic reaction or anaphylaxis to study vaccine components; - report of fever in the 72 hours preceding vaccination (the inclusion can be postponed until the participant completes 72 hours without fever); - possible or confirmed of covid-19 on the day of vaccination (in this situation, vaccination can be postponed until the participant completes 72 hours without symptoms or the diagnosis is ruled out); - have received vaccine with live attenuated virus in the last 28 days or inactivated vaccine in the last 14 days prior to their inclusion in the study, or have immunization scheduled for the first 28 days after their inclusion in the study; - any other condition that, in the opinion of the principal investigator or his medical representative, could jeopardize the safety or rights of a potential participant or that would prevent him from complying with this protocol; - pregnancy or lactating.