inclusion criteria: * laboratory-confirmed diagnosis of covid-19 \<= 14 days prior to randomization * the presence of moderate to severe acute respiratory distress syndrome (ards) as defined by the berlin definition: 1. bilateral chest radiograph infiltrates. 2. pao2:fio2 ratio of less than 200. 3. absence of other clinical conditions that could present in a similar manner (non-infectious pneumonitis, cardiogenic pulmonary edema) * absence of moribund state that would indicate imminent demise and poor chance of survival.

inclusion criteria: * laboratory-confirmed diagnosis of covid-19 \<= 14 days prior to randomization * the presence of moderate to severe acute respiratory distress syndrome (ards) as defined by the berlin definition: 1. bilateral chest radiograph infiltrates. 2. pao2:fio2 ratio of less than 200. 3. absence of other clinical conditions that could present in a similar manner (non-infectious pneumonitis, cardiogenic pulmonary edema) * absence of moribund state that would indicate imminent demise and poor chance of survival.

inclusion criteria: laboratory-confirmed diagnosis of covid-19 <= 14 days prior to randomization the presence of moderate to severe acute respiratory distress syndrome (ards) as defined by the berlin definition: bilateral chest radiograph infiltrates. pao2:fio2 ratio of less than 200. absence of other clinical conditions that could present in a similar manner (non-infectious pneumonitis, cardiogenic pulmonary edema) absence of moribund state that would indicate imminent demise and poor chance of survival.

inclusion criteria: laboratory-confirmed diagnosis of covid-19 <= 14 days prior to randomization the presence of moderate to severe acute respiratory distress syndrome (ards) as defined by the berlin definition: bilateral chest radiograph infiltrates. pao2:fio2 ratio of less than 200. absence of other clinical conditions that could present in a similar manner (non-infectious pneumonitis, cardiogenic pulmonary edema) absence of moribund state that would indicate imminent demise and poor chance of survival.

inclusion criteria: - laboratory-confirmed diagnosis of covid-19 <= 14 days prior to randomization - the presence of moderate to severe acute respiratory distress syndrome (ards) as defined by the berlin definition: 1. bilateral chest radiograph infiltrates. 2. pao2:fio2 ratio of less than 200. 3. absence of other clinical conditions that could present in a similar manner (non-infectious pneumonitis, cardiogenic pulmonary edema) - absence of moribund state that would indicate imminent demise and poor chance of survival.

inclusion criteria: - laboratory-confirmed diagnosis of covid-19 <= 14 days prior to randomization - the presence of moderate to severe acute respiratory distress syndrome (ards) as defined by the berlin definition: 1. bilateral chest radiograph infiltrates. 2. pao2:fio2 ratio of less than 200. 3. absence of other clinical conditions that could present in a similar manner (non-infectious pneumonitis, cardiogenic pulmonary edema) - absence of moribund state that would indicate imminent demise and poor chance of survival.