* females of childbearing potential who are pregnant or unwilling to undergo pregnancy testing; females with a positive pregnancy test on screening day will be excluded. * breastfeeding mothers * patients on ecmo * receiving concurrent treatment with an investigational agent in a clinical trial. * exception: use of covid-19 convalescent plasma is permitted. * more than 72hrs on mechanical ventilation before randomization * receiving concurrent investigational vaccine

* females of childbearing potential who are pregnant or unwilling to undergo pregnancy testing; females with a positive pregnancy test on screening day will be excluded. * breastfeeding mothers * patients on ecmo * receiving concurrent treatment with an investigational agent in a clinical trial. * exception: use of covid-19 convalescent plasma is permitted. * more than 72hrs on mechanical ventilation before randomization * receiving concurrent investigational vaccine

- females of childbearing potential who are pregnant or unwilling to undergo pregnancy testing; females with a positive pregnancy test on screening day will be excluded. - breastfeeding mothers - patients on ecmo - receiving concurrent treatment with an investigational agent in a clinical trial. - exception: use of covid-19 convalescent plasma is permitted. - more than 72hrs on mechanical ventilation before randomization - receiving concurrent investigational vaccine

- females of childbearing potential who are pregnant or unwilling to undergo pregnancy testing; females with a positive pregnancy test on screening day will be excluded. - breastfeeding mothers - patients on ecmo - receiving concurrent treatment with an investigational agent in a clinical trial. - exception: use of covid-19 convalescent plasma is permitted. - more than 72hrs on mechanical ventilation before randomization - receiving concurrent investigational vaccine