1. the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. 2. at the time of randomisation, patients require one of the following 4 ventilatory supports: 1. high-flow oxygen devices. 2. non-invasive mechanical ventilation. 3. invasive mechanical ventilation. 4. extracorporeal membrane oxygenation (ecmo). 3. the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. 4. the patient is pregnant or breastfeeding. 5. the patient has a chronic renal disease is stage 4 or 5 (ccr \<30 ml/min). 6. moderate to severe dementia at the investigator's discretion. 7. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. 8. untreated systemic infections not caused by covid-19. 9. active stomach or duodenal ulcer. 10. recent vaccination with live vaccines. 11. other infection or disease that explains the lung disorder. 12. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. 13. active participation in another clinical study in the last 15 days.

1. the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. 2. at the time of randomisation, patients require one of the following 4 ventilatory supports: 1. high-flow oxygen devices. 2. non-invasive mechanical ventilation. 3. invasive mechanical ventilation. 4. extracorporeal membrane oxygenation (ecmo). 3. the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. 4. the patient is pregnant or breastfeeding. 5. the patient has a chronic renal disease is stage 4 or 5 (ccr \<30 ml/min). 6. moderate to severe dementia at the investigator's discretion. 7. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. 8. untreated systemic infections not caused by covid-19. 9. active stomach or duodenal ulcer. 10. recent vaccination with live vaccines. 11. other infection or disease that explains the lung disorder. 12. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. 13. active participation in another clinical study in the last 15 days.

the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. at the time of randomisation, patients require one of the following 4 ventilatory supports: high-flow oxygen devices. non-invasive mechanical ventilation. invasive mechanical ventilation. extracorporeal membrane oxygenation (ecmo). the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. the patient is pregnant or breastfeeding. the patient has a chronic renal disease is stage 4 or 5 (ccr <30 ml/min). moderate to severe dementia at the investigator's discretion. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. untreated systemic infections not caused by covid-19. active stomach or duodenal ulcer. recent vaccination with live vaccines. other infection or disease that explains the lung disorder. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. active participation in another clinical study in the last 15 days.

the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. at the time of randomisation, patients require one of the following 4 ventilatory supports: high-flow oxygen devices. non-invasive mechanical ventilation. invasive mechanical ventilation. extracorporeal membrane oxygenation (ecmo). the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. the patient is pregnant or breastfeeding. the patient has a chronic renal disease is stage 4 or 5 (ccr <30 ml/min). moderate to severe dementia at the investigator's discretion. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. untreated systemic infections not caused by covid-19. active stomach or duodenal ulcer. recent vaccination with live vaccines. other infection or disease that explains the lung disorder. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. active participation in another clinical study in the last 15 days.

1. the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. 2. at the time of randomisation, patients require one of the following 4 ventilatory supports: 1. high-flow oxygen devices. 2. non-invasive mechanical ventilation. 3. invasive mechanical ventilation. 4. extracorporeal membrane oxygenation (ecmo). 3. the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. 4. the patient is pregnant or breastfeeding. 5. the patient has a chronic renal disease is stage 4 or 5 (ccr <30 ml/min). 6. moderate to severe dementia at the investigator's discretion. 7. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. 8. untreated systemic infections not caused by covid-19. 9. active stomach or duodenal ulcer. 10. recent vaccination with live vaccines. 11. other infection or disease that explains the lung disorder. 12. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. 13. active participation in another clinical study in the last 15 days.

1. the patient's situation is so serious that the doctor in charge thinks he could die within 24 hours. 2. at the time of randomisation, patients require one of the following 4 ventilatory supports: 1. high-flow oxygen devices. 2. non-invasive mechanical ventilation. 3. invasive mechanical ventilation. 4. extracorporeal membrane oxygenation (ecmo). 3. the patient is or has been treated in the 2 weeks prior to randomisation with glucocorticoids or inflammation modifying drugs, both conventional (thiopurines, cyclophosphamide, cyclosporine, tacrolimus), leflunomide, methotrexate, mycophenolate mofetil/mycophenolic acid, sulfasalazine, hydroxychloroquine or chloroquine) as synthetics or biologics directed against therapeutic targets (abatacept, belimumab, cd-20, il1, il6, il12. 23, il-23, il.17, tnf, integrin α4β7 or janus kinase inhibitors jak). patients who are only on maintenance treatment with doses of steroids less than or equal to 7.5 mg of prednisone or equivalent per day will not be excluded. 4. the patient is pregnant or breastfeeding. 5. the patient has a chronic renal disease is stage 4 or 5 (ccr <30 ml/min). 6. moderate to severe dementia at the investigator's discretion. 7. hypersensitivity to any of the active ingredients or to any of the excipients included in its formulation. 8. untreated systemic infections not caused by covid-19. 9. active stomach or duodenal ulcer. 10. recent vaccination with live vaccines. 11. other infection or disease that explains the lung disorder. 12. inability of the patient to understand the study or to sign the informed consent unless consent is delegated to a legal representative. 13. active participation in another clinical study in the last 15 days.